Latuda Has the Greatest Commercial Potential Among New Agents Entering the Bipolar Disorder Drug Market Through 2022
Drug Launches Will Not Offset a Decline in Major-Market Sales Caused By Increasing Generic Competition For Atypical Antipsychotics, According to a New Report from Decision Resources
The Pharmacor advisory service entitled Bipolar Disorder finds that major-market sales in the BPD market will decline by 4.9 percent annually from 2012-2022, resulting primarily from generic competition for Abilify (Bristol-Myers Squibb/Otsuka Pharmaceutical’s aripiprazole), Seroquel/Seroquel extended-release (XR) (AstraZeneca/Astellas quetiapine, AstraZeneca’s quetiapine XR) and other branded agents in the atypical antipsychotic class, such as Geodon/Zeldox (Pfizer’s ziprasidone) and in the antidepressant class, such as Cymbalta (Eli Lilly/Boehringer Ingelheim/Shionogi’s duloxetine). The uptake of Latuda, the launch of Forest Laboratories/
BPD patients are commonly prescribed a combination treatment regimen which typically includes lithium (GlaxoSmithKline’s Eskalith/Eskalith CR, Solvay’s Lithobid/Liskonum/Quilonum, Taisho’s Limas, generics), antiepileptics, antidepressants or atypical antipsychotics–particularly when experiencing acute mood episodes. The prevalence of polypharmacy allows room in the treatment algorithm for adjunctive use of newly marketed and emerging agents. However, in order to achieve uptake, new agents entering the BPD market must positively differentiate themselves from the growing number of generic treatment options available on factors other than cost.
“Unmet need remains for additional drugs with efficacy in treating bipolar depression. Few current therapies have regulatory approval for this indication, and, although antidepressants are frequently prescribed off-label in BPD, interviewed experts express concern over the risk of inducing mania or rapid cycling with antidepressant treatment,” said Decision Resources Business Insights Analyst
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SOURCE Decision Resources