Last updated on April 16, 2014 at 6:45 EDT

Boston Scientific Vercise(TM) Deep Brain Stimulation System Receives CE Mark Approval for Treatment of Dystonia

November 19, 2013

First System To Selectively Stimulate Targeted Areas Of The Brain To Manage Symptoms of Debilitating Disease

NATICK, Massachusetts, November 19, 2013 /PRNewswire/ –

The Boston Scientific Corporation (NYSE: BSX) Vercise(TM) Deep Brain Stimulation (DBS)
System has received CE Mark approval for the treatment of intractable primary and
secondary dystonia, a neurological movement disorder characterized by involuntary muscle

Dystonia affects more than 500,000 people across Europe, including children and
adults. It is the third most common movement disorder after Parkinson’s disease and
essential tremor.[1] Symptoms include involuntary muscle contractions, with twisting,
repetitive movements or abnormal postures, which can be painful and debilitating. The
Vercise DBS System is the first system designed to selectively stimulate targeted areas of
the brain in order to customize therapy and manage symptoms of Parkinson’s disease. This
system now offers new hope for patients with dystonia.

The first implant of the Vercise DBS System for the treatment of dystonia was
performed by a team from the Charite Campus Virchow-Klinikum (CVK), which included Prof.
Dr. Andrea Kuehn, Department of Neurology, and Dr. Gerd-Helge Schneider, Department of
Functional Neurosurgery.

“Historically, treatment of secondary dystonia has been challenging and efficacy was
typically incomplete and partially limited by side effects. The Vercise DBS system
represents an advancement in dystonia care by providing more flexible and unique
programming options for targeted deep brain stimulation tailored to each individual,” said
Prof. Dr. Andrea Kuehn.

“The device itself is designed to offer additional patient benefits including the
longest battery life available for DBS and the smallest implanted stimulator footprint,
especially important for our young patients,” said Dr. Gerd-Helge Schneider.

“The Vercise DBS System’s advanced technology has already demonstrated significant
improvements in motor scores for patients with Parkinson’s disease as evidenced by the
interim results from our VANTAGE multicenter clinical trial,” said Maulik Nanavaty,
president, Neuromodulation, Boston Scientific. “With this approval we look forward to
extending the use of this technology to improve the quality of life of patients with

The Vercise DBS System received CE Mark and Australia TGA (Therapeutic Goods
Administration) approval in 2012 for the treatment of Parkinson’s disease. It is available
in Europe, Israel, Australia and Colombia for such treatment. In the U.S., the Vercise DBS
System is investigational and not available for use or sale.

Click here
[http://bostonscientific.mediaroom.com/index.php?s=24885&mode=gallery&cat=1758 ] to view or
download an image of the Vercise DBS System.

        1) http://dystonia-europe.org Accessed October 2013

About Boston Scientific

Boston Scientific transforms lives through innovative medical solutions that improve
the health of patients around the world. As a global medical technology leader for more
than 30 years, we advance science for life by providing a broad range of high performance
solutions that address unmet patient needs and reduce the cost of healthcare. For more
information, visit http://www.bostonscientific.com or
http://www.bostonscientific-international.com, and connect on Twitter
[http://twitter.com/bostonsci ] and Facebook [http://www.facebook.com/bostonscientific ].

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SOURCE Boston Scientific Corporation

Source: PR Newswire