New TNO Triskelion Lab Tests Vaccines Against Deadly Viruses

March 3, 2014

ZEIST, The Netherlands, March 3, 2014 /PRNewswire/ –

Upgrade to BSL-3 level answers growing global demand for testing facilities

Introduction of a Bio Safety Level 3 (BSL-3) facility and development of special
techniques allow Dutch TNO Triskelion to test vaccines against deadly viruses like avian
flu and SARS. With this step the contract research organisation responds to a globally
growing demand for testing facilities for the development of drugs against these dangerous
infectious diseases. It also allows new vaccines against rapidly mutating (avian)
influenza viruses reach the public sooner.

http://photos.prnewswire.com/prnh/20140303/672923 )

TNO Triskelion performs research activities for the pharmaceutical, chemical and food
industries. The TNO Triskelion facility was recently upgraded to BSL-3 level and
accredited by Public Health England (PHE), so that all class 3 viruses and bacteria deadly
to humans – from HIV to tuberculosis, from avian influenza to SARS – can be studied in
conformity with Good Laboratory Practice (GLP) if required. On a worldwide scale the
testing capacity for vaccines against these viruses is extremely limited. ,,There are few
BSL-3 labs that can do this in compliance with GLP standards, whereas the demand of the
pharmaceutical industry is increasing,” says immunologist John Dulos, senior project
manager pharma at TNO Triskelion. ,,There is a growing need to develop new drugs and
treatments against viral infectious diseases. With this upgrade we increase the testing
capacity. If more drugs can be tested, new vaccines can be introduced sooner.”

Among other things, the BSL-3 facility will be used for research into avian flu. The
Avian Influenza A Virus H7N9 recently appeared in China, taking 40 lives. Virus H5N1 has
been active since 1997, H7N7 has made victims since 2008 and recently a woman in China
died from H10N8. The viruses spread mostly from animals to man. If avian flu evolves into
a virus that transmits from person to person, the threat of a worldwide pandemic is at

Examples of previous pandemics are the Spanish flu in 1918 (40 to 50 million
casualties), the Hong Kong flu in 1968 (1 to 2 million casualties) and the Mexican flu in
2009 (250,000 casualties). TNO Triskelion can test treatments against all subtypes of
Influenza, avian or human.



SOURCE TNO Triskelion

Source: PR Newswire

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