Surveyed U.S. and European Psychiatrists Ascribe the Highest Level of Unmet Need to a Therapy Demonstrating Reduced Use of Opioids in Addicted Patients

March 17, 2014

Developers Continue to Focus Efforts on Formulation Improvements, According to Findings from Decision Resources Group

BURLINGTON, Mass., March 17, 2014 /PRNewswire/ — Decision Resources Group finds that, according to insights from surveyed U.S. and European psychiatrists and U.S. managed care (MCO) pharmacy directors, a therapy resulting in reduced use of opioids compared with existing therapies is one of the greatest unmet needs in the treatment of opioid addiction. Although clinical data and the opinions of interviewed thought leaders indicate that no emerging opioid addiction therapies have demonstrated the potential to fulfill this unmet need to date, the emerging buprenorphine implant (Titan Pharmaceuticals’ Probuphine) is poised to offer a six-month duration of action, which is expected to result in improved compliance and a lower risk of abuse over available buprenorphine-containing products.


Other key findings from the DecisionBase 2014 report entitled Opioid Addiction: How Will Physicians and Payers Value Advances in Drug Delivery?:

    --  Reckitt Benckiser's Suboxone: Clinical data and the opinions of
        interviewed thought leaders indicate that no currently available opioid
        addiction therapies have advantages over sales-leading
        buprenorphine/naloxone sublingual film (Reckitt Benckiser's Suboxone) on
        reducing opioid use.
    --  Price per day for treatment: Decision Resources Group's analysis of
        physician survey results found that of several attributes tested, price
        per day was by a large margin the most important attribute influencing
        surveyed psychiatrists' likelihood of prescribing a given target product
        profile for opioid addiction. In the first half of 2013, generic
        versions of the buprenorphine/naloxone sublingual tablet became
        available, and the availability of these products is expected to lead to
        an even greater importance of price per day in physicians' prescribing
        decisions in the near future.
    --  Dosing frequency: Surveyed U.S. MCO pharmacy directors are notably
        receptive to new opioid addiction therapies that offer less frequent
        dosing over currently available therapies. We expect that Probuphine
        will match the improvements on delivery that surveyed U.S. payers
        indicated would be required for inclusion on MCO formularies.

Comments from Decision Resources Group Analyst Natalie Taylor, Ph.D.:

    --  "The responses from our survey of MCO pharmacy directors indicate that
        improved dosing frequency represents a valuable attribute for an
        emerging opioid addiction therapy. Payers may perceive there is a
        greater likelihood that opioid addiction patients would be compliant
        with their medication if it did not require once-daily dosing."
    --  "Our analysis of physician survey results reveals that a six-month
        dosing interval is not a large enough clinical advantage to overcome the
        negative effect of a high price per treated day on physician preference
        and prescribing likelihood, presumably due to the market access hurdles
        such a therapy would face."

About Decision Resources Group

Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.

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For more information, contact:

Decision Resources Group

Christopher Comfort



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SOURCE Decision Resources Group

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