Surveyed U.S. and European Psychiatrists Ascribe the Highest Level of Unmet Need in Insomnia Treatment to a Therapy with a Reduced Risk of Abuse and Tolerance

April 2, 2014

Both Surveyed Physicians and Payers are Sensitive to the Risk of Next-Day Impairment with Insomnia Therapies, According to Findings from Decision Resources Group

BURLINGTON, Mass., April 2, 2014 /PRNewswire/ — Decision Resources Group finds that surveyed U.S. and European psychiatrists ascribe the highest level of unmet need in insomnia treatment to be for new therapies with a reduced risk of abuse and tolerance. Several currently available insomnia therapies are designated as controlled substances owing to their potential for abuse, and interviewed thought leaders acknowledge abuse potential as a factor they consider when making prescribing decisions for insomnia. Although other available insomnia drugs are not controlled substances, surveyed psychiatrists identify reduced risk of abuse and tolerance as an area of differentiation for a novel therapy. However, given that the insomnia market is highly genericized, an emerging therapy will have to offer significant improvements on safety and efficacy, not only on abuse potential, to penetrate the market.


Other key findings from the DecisionBase report entitled Insomnia: In the Highly Genericized Insomnia Market, What Opportunities Remain for New Therapies?:

    --  Lunesta and Suvorexant: Based on clinical data and the opinions of
        interviewed thought leaders, suvorexant (Merck & Co.'s MK-4305) has
        clinical advantages over Lunesta (Dainippon Sumitomo/Sunovion
        Pharmaceuticals/Eisai) in terms of safety and tolerability, specifically
        a lower incidence of psychomotor events and residual next-day effects at
        the doses deemed approvable.
    --  Unmet need: In addition to the need for a therapy bearing a reduced risk
        of abuse and tolerance, surveyed psychiatrists identify significant
        unmet need for therapies associated with reduced residual next-day side
        effects, such as residual sedation. This finding is consistent with
        insight from interviewed sleep experts, who call for a novel insomnia
        medication with a more favorable pharmacokinetic profile, in turn
        reducing the frequency of next-day side effects.
    --  Formulary inclusion: Surveyed U.S. managed care organization pharmacy
        directors are receptive to reimbursing a novel insomnia therapy offering
        improvements in time awake after sleep onset and in the number of
        patients reporting next-day sleepiness, but they would require one
        hundred percent or more improvement in these metrics over that attained
        by current therapies. Therapies offering such robust benefits could
        nevertheless command a premium price in this market but payers would
        control costs by requiring step therapy and prior authorization.

Comments from Decision Resources Group Analyst Tamara Blutstein, Ph.D.:

    --  "The potential for a patient to develop abuse and tolerance with
        insomnia medications is a concern among interviewed psychiatrists, who
        take this risk into consideration when prescribing an insomnia therapy.
        Reduced risk for tolerance or dependence is an area where surveyed
        payers express a high willingness to grant favorable formulary status
        for a new insomnia therapy and where surveyed physicians identify unmet
        need in insomnia treatment."
    --  "The longer the half-life of a drug, the more effective it is at
        addressing sleep maintenance insomnia, unfortunately, the more likely it
        is to harbor residual next-day side effects.  Interviewed psychiatrists
        note that no available insomnia therapies offer patients the ideal
        balance of a full night sleep without next-day impairment."

About Decision Resources Group

Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.

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Decision Resources Group

Christopher Comfort



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SOURCE Decision Resources

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