For Treatment of Ulcerative Colitis (UC), Great Opportunity Exists for Vedolizumab in the U.S. and EU5 Market, Owing to its Novel Mechanism of Action and Promising Efficacy

April 21, 2014

Mucosal Healing and Maintenance of Remission Have High Influence in Gastroenterologists’ Prescribing Decision for UC, According to Findings from Decision Resources Group

BURLINGTON, Mass., April 21, 2014 /PRNewswire/ — Decision Resources Group finds that, according to surveyed U.S. and EU5 gastroenterologists, effect on mucosal healing and improvement in the maintenance of remission are two of the attributes that most strongly influence their prescribing decisions in moderate to severe ulcerative colitis. Emerging therapies that offer improved effect in these attributes over current therapies would be well received and poised for strong uptake. Based on thought leaders’ opinions and clinical trial data, Takeda’s vedolizumab (Entyvio) has great potential owing to its improved efficacy in the maintenance of remission and long-term mucosal healing.


Other key findings from the DecisionBase report entitled: Ulcerative Colitis (moderate to severe): Amid significant unmet need, what attributes do gastroenterologists and payers expect of a therapy with a mechanism of action different from the currently available TNF-alpha inhibitors?:

    --  Surveyed U.S. and EU5 gastroenterologists place great importance in
        their prescribing decision on therapies that improve efficacy, followed
        by therapies that offer improvement in safety and/or delivery. Yet,
        surveyed gastroenterologists also note a high unmet need for therapies
        that offer a lower risk of serious/opportunistic infections and a more
        convenient dosage formulation.
    --  Surveyed U.S. managed care organization pharmacy directors agree that
        improvements in efficacy is the driving force behind their decision on
        granting an agent favorable formulary status. Delivery improvements may
        strengthen a therapy's reimbursement prospects, though such advances
        will likely need to be accompanied by other clinically meaningful
        therapeutic gains.
    --  The Emerging therapy Entyvio has the potential to fulfill
        gastroenterologists' and payers' unmet needs based on its strong
        maintenance of remission. Pfizer's oral Xeljanz has the advantage of
        being a safe therapy for ulcerative colitis, with a low burden of

Comments from Decision Resources Group Analyst Adi Reske, Ph.D.:

    --  "Gastroenterologists consistently express the need for new therapies
        with improved efficacy, lower risk of adverse events and better
        delivery. Emerging therapies for ulcerative colitis offer to fulfill
        some of these unmet needs; however, given physicians' established
        long-term experience with the anti-TNF-alpha inhibitors, new therapies
        in the moderate to severe ulcerative colitis market will likely be
        reserved for the TNF-refractory subpopulation."
    --  "Price is a determining factor in decision making for both
        gastroenterologists and payers. However, therapies for moderate to
        severe ulcerative colitis that offer improvement on induction and
        maintenance of remission over current therapies would be eligible for
        substantial price premiums."

About Decision Resources Group

Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.

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Decision Resources Group

Christopher Comfort



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SOURCE Decision Resources Group

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