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Arthritis Blood Test: 14-3-3 eta Ground-Breaking Data

May 29, 2014

VANCOUVER, May 29, 2014 /PRNewswire/ – Augurex Life Sciences Corp. announces a ground-breaking body of new data that will publish during the European League Against Rheumatism (EULAR) Annual Congress of Rheumatology taking place June 11-14 in Paris. Investigators will present the studies listed in the schedule below, which to date along with other publications, represent over 2000 patients evaluated with the 14-3-3 eta blood test.

This follows the very recent publication of a study describing the novel mechanism by which 14-3-3 eta promotes disease. Rheumatoid arthritis (RA) develops from an interplay of several factors that lead to inflammation and joint damage, making it a particularly debilitative form of arthritis affecting about 1.5% of the population. Many of these factors have been known for decades, with the 14-3-3 eta protein now representing the most novel discovery of the past 7 years. The key is that 14-3-3 eta is a protein normally present inside cells, in all of us. However in patients who develop certain forms of arthritis 14-3-3 eta gets outside the cell and causes numerous harmful effects, implicating it directly in the disease process.

Augurex’ Chief Scientific Officer, Dr. Anthony Marotta says “This protein is a scientist’s dream because before its discovery in 2007, no one knew that it played a role in arthritis. It’s not only exciting for Augurex and our international investigators to uncover the ways in which it causes disease, but also for patients and the rheumatology community at large.” Dr. Marotta adds, “14-3-3 eta, and the related blood tests, will address so many autoimmune conditions which risk joint involvement, ultimately helping prevent disease development and progression. We can’t wait to see what the world learns from this protein through international research and clinical use”.

Dr. Marotta will be giving a web-based presentation on Friday, May 30th at 9:00 am PST entitled How does the soluble mechanistic biomarker 14-3-3 eta assist in the management of Rheumatoid Arthritis?”. The 14-3-3 eta blood test is available in the United States and will launch in Canada in the coming months.

Dr. Walter Maksymowych, the principal investigator of several 14-3-3 eta studies as well as the International Chair of the Outcomes Measures in Rheumatology Clinical Trials Soluble Biomarker Subcommittee and Medical Research Professor of Medicine and Rheumatologist at the University of Alberta, says “The body of evidence is now growing at such a rapid rate that we are seeing applications emerge in autoimmune diseases such as Ankylosing Spondylitis, where there are no useful diagnostic blood tests available.” Dr. Maksymowych adds, “This protein can potentially change our perspective of disease mechanisms and open up a whole new area of research that could improve the lives of these patients.”

List of 14-3-3 eta EULAR 2014 Conference Proceedings

    Title                  Date and Time            Location
    -----                  -------------            --------

    14-3-3eta predicts
     radiographic
     progression in
     recent-onset
     polyarthritis
     patients              Poster Tour Presentation Room 251

    Presenter: Gilles
     Boire                 June 13, 12:00 - 13:15

    Abstract # SAT0041
    ------------------

    Poster Presentation    Poster area A, level 1

    June 14, 10:15 - 12:00
    ----------------------

    93% of early RA
     patients are
     positive for 14-3-
     3eta markers and 14-
     3-3eta auto-
     antibodies inform a
     favourable
     prognosis,
     irrespective of RF
     or ACPA status        Poster Tour Presentation Level 3

    Presenter: Dirkjan
     van Schaardenburg     June 14, 10:30-11:45

    Abstract # FRI0226
    ------------------

    Poster Presentation    Poster area D, level 4

    June 13, 11:45-13:30
    --------------------

    Auto-antibodies to a
     specific 14-3-3eta
     epitope is a marker
     of ankylosing
     spondylitis, is
     associated with SIJ
     inflammation and
     predicts
     radiographic
     progression           Poster Presentation      Poster area A, level 1

    Presenter: Walter
     Maksymowych           June 12, 11:45-13:30

    Abstract # THU0105
    ------------------

    14-3-3eta is an
     independent
     predictor of
     radiographic changes
     in early RA and
     higher titres inform
     a higher likelihood
     of joint damage
     progression           Poster Presentation      Poster area D, level 4

    Presenter: Dirkjan
     van Schaardenburg     June 12, 11:45-13:30

    Abstract # THU0244
    ------------------

    Evaluation of serum
     14-3-3eta levels in
     a Japanese RA cohort
     treated with
     tocilizumab           Poster Presentation      Poster area D, level 4

    Presenter: Akira
     Sagawa                June 12, 11:45 to 13:30

    Abstract # THU0226
    ------------------

    Lower levels of 14-
     3-3eta predict
     DMARD-associated
     DAS remission at 1
     year follow up        Poster Presentation      Poster area A, level 1

    Presenter: Dirkjan
     van Schaardenburg     June 13, 11:45-13:30

    Abstract # FRI0002
    ------------------

    Serum 14-3-3eta
     predicts the risk of
     RA development and
     its higher titres
     are associated with
     higher risk           Poster Presentation      Poster area A, level 1

    Presenter: Dirkjan
     van Schaardenburg     June 14, 10:15-12:00

    Abstract # SAT0037
    ------------------

    Levels of 14-3-3eta
     predict Good EULAR
     response to anti-
     TNF treatment in
     patients with
     rheumatoid arthritis  Poster Presentation      Poster area A, level 1

    Presenter: Walter
     Maksymowych           June 14, 10:15-12:00

    Abstract # SAT0070
    ------------------

    14-3-3eta biomarker
     dynamics in CIA mark
     disease severity in
     a non-
     interventional study
     Abstract # AB0152      Abstract
    ---------------------  --------

    14-3-3eta clinical
     assays are
     equivalent and RF
     does not interfere
     with its
     quantitation
     Abstract # AB0941      Abstract
    -------------------    --------

SOURCE Augurex Life Sciences Corp.


Source: PR Newswire



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