Spinifex Pharmaceuticals Appoints Neuroscience Expert Dr Ronald Marcus as Chief Medical Officer

June 3, 2014

MELBOURNE, Australia and STAMFORD, Connecticut, June 3, 2014 /PRNewswire/ –

Spinifex Pharmaceuticals, a pain drug development company, today announces that it has
appointed Dr Ronald Marcus as Chief Medical Officer. Dr Marcus will be responsible for
driving the development of Spinifex’s lead candidate EMA401 and the Company’s pre-clinical
pipeline. He takes up his position immediately.

EMA401 is a novel angiotensin II type 2 (AT2) receptor antagonist being developed as a
potential first-in-class oral treatment for chronic pain without CNS side-effects. Current
treatments for chronic pain do not relieve pain in all individuals and so drugs targeting
a new approach to pain treatment are needed.

Dr Marcus has more than 20 years’ pharmaceutical clinical development experience. He
joins Spinifex after a successful career at Bristol-Myers Squibb (BMS), having held a
number of senior leadership positions within BMS’s Neuroscience division.

Dr Marcus was most recently Executive Director, Neuroscience Global Clinical Research
at BMS. In this role he was Early Development Team Leader for neuropathic pain,
schizophrenia and migraine compounds and Life-Cycle Management (LCM) Team Leader for
Abilify. He has extensive experience in early and late drug development process and
possesses both breadth and depth in all of the key functional areas of exploratory and
late development, disease biology and regulatory affairs. Dr Marcus has been recognized
within industry for his excellence in overall drug development, innovative strategic
leadership and executional excellence while spearheading an industry leading life cycle
management program for Abilify. In addition to the approval of over 20 NDAs and sNDAs
globally for Abilify, Dr Marcus also led the successful development of Serzone, an

Dr Marcus received a BA in Psychology from University of Virginia. He earned his
medical degree from SUNY Buffalo and completed his Psychiatry residency and NIMH research
fellowship at Cornell University, New York Hospital-Westchester Division. He has authored
more than 80 peer-reviewed publications.

Spinifex’s CEO Tom McCarthy said: “Recruiting someone of Ron’s calibre as Chief
Medical officer is an important development for Spinifex as we build our clinical
development and senior management team. Ron’s appointment, plus the recent expansion of
our Scientific Advisory Board with internationally renowned experts in chronic pain, is a
strong recognition of our high quality science and the potential for EMA401 to become a
new chronic pain treatment. Following our recent $45 million fundraising, we are making
excellent progress in preparing for further Phase 2 clinical trials of EMA401 in a range
of chronic pain indications.”

Dr Marcus added: “The treatment of chronic pain remains a high unmet need, as current
therapies have limited efficacy or potentially serious side-effects. Spinifex has done an
excellent job so far in developing a potentially new treatment for chronic pain and
importantly without CNS side-effects. I am very pleased to be joining the Company during
its next development phase and leading its clinical programs.”

Positive results of Spinifex’s Phase 2 clinical trial of EMA401 in postherpetic
neuralgia (PHN), a painful condition that develops in some patients following herpes
zoster (shingles), have been published in The Lancet[1]. Spinifex is planning a Phase 2b
study with EMA401 in PHN, and investigating it in neuropathic and inflammatory pain
conditions such as osteoarthritis, chemotherapy induced neuropathy and peripheral diabetic
neuropathy. The Company also intends to conduct further pre-clinical research on AT2
receptor antagonists in pain, including the company’s follow on candidate program.

Spinifex Pharmaceuticals

Spinifex Pharmaceuticals is an Australian-US biotechnology company developing new drug
candidates for the treatment and management of pain.

Established in 2005 and based in Stamford, Connecticut and Melbourne, Australia,
Spinifex has applied its world-class drug development capabilities to advance product
candidates. Its lead product EMA401 is under development as a potential first-in-class
oral treatment for chronic pain without CNS side effects. Spinifex’s Phase 2 program for
EMA401 includes clinical trials in a number of chronic pain conditions. Spinifex’s
investors are Novo A/S, Canaan Partners, GBS Venture Partners, Brandon Capital Partners,
Uniseed and UniQuest.


        For more information please contact:

        Dr Tom McCarthy
        CEO Spinifex Pharmaceuticals
        Tel: +1-203-989-2100
        Email: info@spinifexpharma.com

        Chris Gardner/Sita Shah
        Citigate Dewe Rogerson
        Tel: +44(0)20-7638-9571
        Email: sita.shah@citigatedr.co.uk


1. EMA401, an orally administered highly selective angiotensin II type 2 receptor
antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind,
placebo-controlled phase 2 clinical trial, Rice, A.S.C. et al. (2014) The Lancet. 383
(9929), 1637-1647.

SOURCE Spinifex Pharmaceuticals

Source: PR Newswire

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