Glenmark Pharmaceuticals Inaugurates New Antibody Manufacturing Facility in La Chaux-de-Fonds, Switzerland

June 4, 2014

MUMBAI and LA CHAUX-DE-FONDS, Switzerland, June 4, 2014 /PRNewswire/ –

– State-of-the-art Manufacturing Facility for Supply of Clinical Trial Material

– With the Facility Glenmark has end-to-end Capabilities for the Development of Novel,
State-of-the-art Monoclonal Antibodies Including Bi-specific Antibodies

Glenmark Pharmaceuticals S.A (GPSA), a wholly-owned subsidiary of Glenmark
Pharmaceuticals Limited, India (GPL), announced the opening of its new cGMP compliant
monoclonal antibody manufacturing facility in La Chaux-de-Fonds, Switzerland. This
manufacturing facility supplements Glenmark’s existing in-house discovery and development
capabilities and will supply material for clinical development.



Glenmark Pharmaceuticals’ Swiss research center is an integrated antibody discovery
and development unit. The research center has fully developed in-house capabilities and
infrastructure for conducting antibody discovery, cell line development, in vitro testing
and characterization of antibodies, process development and analytical research. The new
manufacturing facility supplements the research and development capabilities and will
facilitate production of clinical grade material.

The manufacturing facility has been designed for use of single use bioreactor systems
and also houses a suite for manufacturing cell banks. The facility is fully compliant with
quality, environmental and safety standards for manufacturing clinical trial material.

Dr. Michael Buschle, President – Biologics, Glenmark Pharmaceuticals Ltd. commented,
“This state-of-the-art manufacturing facility is a testimony for Glenmark’s commitment to
growing its R&D and manufacturing facility in the canton of Neuchatel. We have been doing
cutting-edge work in the area of novel monoclonal antibodies and have several monoclonal
antibody candidates and bispecific antibodies in the pipeline. The manufacturing facility
would help us bring these antibodies to the clinic faster and position Glenmark as a
leading innovative pharmaceutical company.”

Glenmark’s biologics research center in Switzerland has a robust pipeline of
monoclonal antibodies in various stages of development including bispecific antibodies.
The focus for the biologics R&D center is to develop novel biologic entities for the
treatment of pain, inflammatory, oncologic and respiratory conditions. Glenmark currently
has 69 employees at its biologic research center.

In its short existence of just about 10 years, Glenmark’s biologics research center
has filed several patents on novel biologic entities. GBR 500, its most advanced
candidate, has been licensed to Sanofi and is currently in Phase 2 development. GBR 900, a
first-in-class molecule for treatment of chronic pain, is currently in Phase 1 and GBR
830, an anti OX-40 antagonist, is scheduled to enter the clinic later this year. The
scientists at Glenmark have also invented a best-in-class technology platform to
manufacture bispecific antibodies, BEAT(TM) [http://www.glenmarkpharma.com/beat ].

About Glenmark Pharmaceuticals

Glenmark Pharmaceuticals Ltd. (GPL) is a research-driven, global, integrated
pharmaceutical company headquartered at Mumbai, India. It is a leading player in the
discovery of new molecules, both NCEs (new chemical entity) and NBEs (new biological
entity). Glenmark has six molecules in various stages of clinical development and is
primarily focused in the areas of Inflammation [asthma/COPD, rheumatoid arthritis, IBD,
etc.] and Pain [neuropathic pain and inflammatory pain]. The company has a significant
presence in branded generics markets across emerging economies including India. Glenmark
has 13 manufacturing facilities in four countries and has six R&D centres.




SOURCE Glenmark Pharmaceuticals

Source: PR Newswire

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