The Effects of Weight Loss and Weight Gain on Insulin-Like Growth Factor (IGF)-1 and IGF Binding Proteins in Premenopausal Women
Posted on: Tuesday, 21 December 2004, 03:00 CST
The Effects of Weight Loss and Weight Gain on Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins in Premenopausal Women. M. Harvie,* T. Mercer,[dagger] R. Malik,** J. Adams,** J. Frystyk,[double dagger] A. Flyvbjerg,[double dagger] C. Wale,[dagger][dagger] and A Howell.* *South Manchester University Hospitals Trust, Manchester, UK; [dagger]Department of Exercise and Sports Science, Manchester Metropolitan University, Manchester, UK; **Department of Clinical Radiology, University of Manchester, Manchester, UK; [double dagger]Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Aarhus, Denmark; and [dagger][dagger]Cancer Research, UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventative Medicine, London, UK.
Weight loss reduces risk of breast cancer but the mechanism of this risk reduction is not known. Weight loss has been linked to increases in serum levels of insulin-like growth factor binding protein 1 (IGFBP-1), which is believed to reduce levels of the mitogen free IGF-I. Few direct measurements have been made of the effects of weight loss on free IGF-I. We examined the effects of a 12-mo calorie-restricted and exercise weight loss program as compared with standard diet and exercise advice on serum levels free IGF-I, total IGF-I, IGFBP-1, IGFBP-2, and insulin in 74 premenopausal women (aged 35-45), with relatively large adult weight gains (>10 kg since age 20) and a family history of breast cancer (1 in 6 lifetime risk or greater). Body weight, body fat (dual-energy X- ray absortiometry), intraabdominal fat (IAF; by MRI), fasting free IGF-I, total IGF-I, IGFBP-I, IGFBP-2, and insulin were determined at baseline and 12 mo. We report correlations between percent change in weight, body fat (kg), and IAF with percent change in serum levels of the IGF peptides and insulin over 12 mo. Weight change over the year ranged from -16.3% to + 9.75% (median -1.6%). Pearson correlation analyses confirmed that change in IGFBP-I had a significant negative correlation to change in weight, body fat, and intraabdominal fat. Change in free IGF-I also had a significant negative correlation to change in intraabdominal fat. The unexpected increase in free IGF-I alongside loss of intraabdominal fat in this population suggest that reductions in cancer risk with weight loss are unlikely to be mediated by changes in the IGF axis.
Pearson correlations between % change in body size and peptide hormones after a 12-mo weight loss program
Copyright American Institute of Nutrition Dec 2004
Source: Journal of Nutrition, The
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