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Scientists Seek New Asthma, COPD Treatment

Posted on: Tuesday, 4 December 2007, 15:00 CST

Scientists at Britain's University of Nottingham have received nearly $2.5 million to explore causes and possible treatments for respiratory diseases.

The Wellcome Trust awarded Professor Alan Knox and Linhua Pang $1.4 million to research transcriptional control of inflammatory gene expression in asthma. That study will focus on the part inflammatory mediators play in the way asthma sufferers react to allergens.

A second grant of $1.1 million was awarded Professors Knox, Peter Fischer and David Heery to investigate compounds that could combat the symptoms of asthma and chronic obstructive pulmonary disease.

The majority of people with asthma have access to reasonably good anti-inflammatory treatments that can keep their conditions under control, said Know. "But up to 20 percent of sufferers don't respond well to the treatments currently available. And when it comes to COPD, anti-inflammatory drugs aren't very effective.

By tracking the process which triggers the inflammation and then identifying the compounds that inhibit or activate these crucial enzymes, we could put into motion the development of a drug which could have a huge impact on the lives of those suffering from respiratory and other inflammatory diseases, Knox added.


Source: United Press International

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