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'Triple Analysis: Antibody Drug Target Atlas in Oncology and Special Focus on Breast- And Prostate Cancer' Provides a Framework and a Careful Evaluation of Drug Candidates, Technologies and Competitors

Posted on: Friday, 11 January 2008, 12:00 CST

Research and Markets (http://www.researchandmarkets.com/reports/c79346) has announced the addition of Triple Analysis: Antibody Drug Target Atlas in Oncology and Special Focus on Breast- and Prostate Cancer to their offering.

In this triple analysis report the author has analyzed three major and intertwined areas of cancer R&D, Antibody drug targets, Breast- and Prostate cancer, which are all subjects to an extensive number of innovative drug candidates. This extensive 380+ pages report compiles and analyzes in parallel the progress concerning drug development and competitive situation in Antibody drug targeting and further give an in depth analysis in two key oncology areas; Breast- and Prostate cancer. The report will not only provide a framework but also a careful identification and evaluation of drug candidates, technologies and competitors.

There are currently more than 400 antibody based drugs in development for the treatment of cancer. The author has surveyed these antibodies and identified 132 antibody drug targets, belonging to 220 antibody drugs. In all they range from preclinical development to established therapy leaders in the market place. In total more than 420 clinical trials are included in this analysis, covering more than 30 different cancer indications plus diagnosis and supportive care.

Drug targets and their associated antibodies have been analyzed by the author according to:

- 34 Different molecular functions of target

- 13 Major signaling pathways

- Cancer stem cells

- Conjugated antibodies

- Therapeutic effects: Anti-angiogenesis, Apoptosis and Protein Kinase Inhibition

- 31 Targeted cancer indications

- Availability of expression profiles of targets in human tissues, cancer tissues, established cell lines and primary cell cultures

- Antibody therapeutic companies

In breast cancer we have identified 170 drug candidates in clinical stage of development and more than 100 companies are involved in the development of these drugs. As a treatment for breast cancer hormone modifying therapies together with different chemotherapeutic schedules have been of highest interest during the last years of progress. A vast amount of new clinical research data has emerged and several new clinical trials have been iniated and others generated new results. Protein kinase inhibitors and epothilones have generated substantial amount of new research data in this field. But, other strategies seem not successful and we are still waiting new information regarding their progress.

In prostate cancer we have identified 127 drug candidates in phase II or III stage of development and more than 85 companies are involved in the development of these drugs. Two of the most successful strategies are apoptosis inducers and cell based vaccines. Three out of 10 late stage candidates are apoptosis inducers. Cell based vaccines has been tried for some time but has so far failed to generate substantial improvements.

Breast and Prostate Cancer Highlights

- Thorough examination of status and impact of several novel drugs in development

- Discussion of the challenges in current and future treatment strategies

- Anticancer pipeline of most companies in the field

Key reasons to read this report

- This report serves as a serious reference for professionals interested in the development of oncology drug targets and selection/validation of targeting strategies.

- Explore the strengths and weaknesses associated with compounds in clinical development. Scientific rationale for most novel therapeutics in breast- and prostate cancer R&D, and the results of clinical trials to date.

- Gain insight into the current challenges and commercial opportunities associated with breast- and prostate cancer therapy.

Content Outline:

1 Executive Summary

2 Methodologies

3 Table of Contents

4 Antibody Drug Target Analysis in Oncology: What and Where Are We Targeting?

5 Antibody Drug Targets by Molecular Function

6 Antibody Drugs Targeting Signaling Pathways

7 Antibodies Targeting Cancer Stem Cells

8 Targets of Antibody Conjugates

9 Antibody Drug Targets by Three Major Non Immunological Therapeutic Effects

10 Antibody Targets and Drugs by Cancer Indications

11 Expression Profiles of Antibody Drug Targets

12 Breast Cancer: An Introduction

13 Current Treatment Strategies of Breast cancer

14 Progress in Current Breast Cancer Treatment Strategies

15 Key Therapeutic Strategies for Future Breast Cancer Therapies

16 Competitive Landscape in Breast Cancer Drug Development: The Late Stage Pipeline

17 Current Drug Development for Breast Cancer: The Early Stage Pipeline

18 Prostate Cancer: An Introduction

19 Current Prostate Cancer Treatment Strategies

20 Progress in Current Prostate Cancer Treatment Strategies

21 Key Therapeutic Strategies for Future Prostate Cancer Therapies

22 Competitive Landscape in Prostate Cancer Drug Development: The Late Stage Pipeline

23 Current Prostate Cancer Drug Development: The Early Stage Pipeline

24 Disclaimer

25 Drug Index

26 Company Index

27 Appendix I: Antibody Targets by Companies

3.1 List of Figures

3.2 List of Tables

3.3 List of Boxes

For more information visit http://www.researchandmarkets.com/reports/c79346.

Source: Business Wire

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