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Stem Cells Aid Peripheric Vascular Disease

Posted on: Thursday, 24 January 2008, 21:00 CST

Stem cells extracted from bone marrow, known as MAPCs, have proven effective in treating peripheric vascular disease, a Spanish and Belgian study said.

Felipe Prosper of the University Hospital of Navarra in Pamplona, Spain, and Aernout Luttun and Catherine M. Verfaille of the Catholic University of Leuven, Belgium, said that acute peripheric vascular disease, or PVD, involves the obstruction of the blood circulation.

If it is not treated in time, the ischemia -- restriction in blood supply -- can cause various complications with the worst scenario being tissue necrosis, gangrene, or the loss of a limb.

The study, published in The Journal of Clinical Investigation, found adult MAPC stem cells are more effective when injected just as they were extracted from bone marrow, not only because they contribute in increasing the quantity of arteries and veins generated in the new area, but also because they manage to enhance muscle regeneration.

The study was carried out on both cell populations from mice as well as humans. The experiments undertaken with MAPCs from mice and those from humans overlap -- they both achieve identical benefits, the study said.


Source: United Press International

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