Cytheris Reports Promising Results From Phase I/II HIV Trial
Posted on: Wednesday, 13 February 2008, 12:00 CST
Cytheris has reported positive results of the long-term follow-up of patients in a multi-center Phase I/II study of Interleukin-7/IL-7 therapy in chronically HIV-1 infected patients, whose CD4+ T-cell counts remained low despite treatment with anti-retroviral-therapies or HAART.
The Phase I/II trial was designed to investigate the safety of IL-7 therapy in chronically HIV-1 infected patients with low CD4 counts (100-400 CD4+/µl) and plasma HIV RNA <50 cp/ml for at least six months while on HAART.
The long-term results for this group of patients, defined as immune non-responders, indicate that the IL-7 induced rapid expansion of CD4+ and CD8+ T-cell counts was sustained up to 48 weeks from study entry. Importantly, 48 weeks after initiation of this IL-7 short course of treatment, patients treated at the 10µg/kg dose level showed a median increase in CD4+ and CD8+ T-cell counts (cells/µL) of 75% and 57%, respectively, from baseline levels.
Source: Datamonitor
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