Primary Tumor SUV and NSCLC

By Anonymous

In the January issue of the Journal of Thoracic Oncology (2008;3:6-12), Berghmans and members of the European Lung Cancer Working Party for the International Association for the Study of Lung Cancer reported on a metaanalysis of the literature conducted to derive a consensus view of the prognostic value of primary tumor standardized uptake values (SUVs) in non-small cell lung cancer (NSCLC). Thirteen eligible studies (total of 1,474 patients) were identified with die information required to perform the target analysis, which involved extracting estimates of the hazard ratio (HR) for comparing patients with low and high SUVs. Using data from these studies, the researchers aggregated individual HRs into a combined HR using a random-effects model. Eleven of the studies identified a high SUV as a prognostic factor for shorter survival, and 2 studies found no significant correlation between SUV and survival. The combined HR for the 13 reports was 2.27. The authors concluded that these results suggest “that the primary tumor SUV measurement has a prognostic value in NSCLC” and that these results should be confirmed in a metaanalysis focusing on individual patients’ data. Journal of Thoracic Oncology

Copyright Society of Nuclear Medicine Mar 2008

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