March 30, 2008
Hair Follicle Stem Cells May Help New Blood Vessel Growth
For a rich source of stem cells to be engineered into new blood vessels or skin tissue, clinicians may one day look no further than the hair on their patients' heads, according to new research published earlier this month by University at Buffalo engineers.
"Engineering blood vessels for bypass surgery, promoting the formation of new blood vessels or regenerating new skin tissue using stem cells obtained from the most accessible source -- hair follicles -- is a real possibility," said Stelios T. Andreadis, Ph.D., co-author of the paper in Cardiovascular Research and associate professor in the Department of Chemical and Biological Engineering in the UB School of Engineering and Applied Sciences.
Researchers from other institutions previously had shown that hair follicles contain stem cells.
In the current paper, the UB researchers demonstrate that stem cells isolated from sheep hair follicles contain the smooth muscle cells that grow new vasculature. The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells.
"We have demonstrated that engineered blood vessels prepared with smooth muscle progenitor cells from hair follicles are capable of dilating and constricting, critical properties that make them ideal for engineering cardiovascular tissue regeneration," said Andreadis.
In addition to growing new skin for burn victims, cells from hair follicles could potentially be used to engineer vascular grafts and possibly regenerate cardiac tissues for patients with heart problems.
Since smooth muscle cells comprise the muscle of numerous tissues and organs, including the bladder, abdominal cavity and gastrointestinal and respiratory tracts, this new, accessible source of cells may make possible future treatments that allow for the regeneration of these damaged organs as well.
Andreadis and his colleagues previously engineered functional and implantable blood vessels with smooth muscle and endothelial cells originating from bone-marrow mesenchymal stem cells.
A key advantage of mesenchymal cells is that they typically do not trigger an immune reaction when transplanted, he said.
"Preliminary experiments in our laboratory suggest an exciting possibility -- that stem cells from hair follicles may be similar to bone-marrow mesenchymal cells," Andreadis said.
"The best case scenario is that from this one very accessible and highly proliferative source of stem cells, we will be able to obtain multiple different cell types that can be used for a broad range of applications in regenerative medicine," he said.
Co-authors on the paper are Jin Yu Liu, Ph.D., research assistant professor, and Hao Fan Peng, a doctoral candidate, both in the UB Department of Chemical and Biological Engineering.
The work was funded by the John R. Oishei Foundation of Buffalo. Previous work by Andreadis has been funded by UB's Integrative Research and Creative Activities Fund in the UB Office of the Vice President for Research.
The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system that is its largest and most comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.
Photo Caption: Research by Stelios Andreadis has produced this smooth muscle progenitor cell derived from a hair follicle, which expresses calponin (in red), a marker for smooth muscle cells. The cell nucleus is shown in blue.
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