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Drugs May Cut Heart Risks ; Study Says High Doses Aid Clogged Arteries

Posted on: Wednesday, 9 March 2005, 15:00 CST

ORLANDO, Fla. - Giving people with modestly clogged arteries very high doses of a drug to drive their cholesterol down to very low levels cut their risk of strokes and heart attacks even more impressively than expected, the first study to test this strategy found.

Although some patients developed liver problems that forced them to stop taking the medication, researchers believe the benefits of this approach outweigh its risks. Still, specialists said more study is needed to establish its safety before it can be recommended.

"This was a very gutsy study," said Dr. John LaRosa of State University of New York in Brooklyn, who led the large international study. "This is new territory."

He presented the findings Tuesday at an American College of Cardiology meeting in Orlando. They also were published online by the New England Journal of Medicine and will be in its April 7 issue.

Statin drugs such as Lipitor, Zocor and Mevacor have shown an impressive ability to lower LDL or "bad" cholesterol and reduce the risk of heart trouble. Recently, some doctors have advocated a much more aggressive strategy of driving cholesterol levels down even farther for certain people.

A study of this approach was funded by and involved many doctors with ties to Pfizer Inc., which makes Lipitor. It is one of six statins on the market. Guidelines advise people at high risk of a heart attack to get LDL to 70 and those at moderate risk to aim for 100.

A previous study found that giving high-dose statins to lower cholesterol below 100 helped people who recently suffered a heart attack. This study, in contrast, involved people who had clogged heart arteries that occasionally cause chest pain but were in no immediate danger of a heart attack. Up to 13 million Americans are in that category.

About 10,000 people in 14 countries took either 10 milligrams or 80 milligrams of Lipitor and brought their LDL levels to 101 and 77, respectively.

After nearly five years, 10.9 percent of those on the low dose had died or suffered a stroke, heart attack or other big problem, compared with 8.7 percent on the high dose. That means that patients on high doses had a 22 percent lower risk.

That is better than doctors had expected, LaRosa said.

"Most of us thought that when you got to 100, going lower would be marginal at best," he said.

However, about 1.2 percent developed signs of liver inflammation on the high dose versus 0.2 percent of the others, which is in line with other studies that tested high doses of statins.

Usually the inflammation clears up when people are taken off the drug, but patients would need to be aggressively tested and monitored for this condition, said Dr. Sidney C. Smith, an American Heart Association spokesman and cardiologist at the University of North Carolina.

Results also might vary with a different statin, he said. Other brands are Bristol-Myers Squibb's Pravachol, Novartis Pharmaceuticals' Lescol, AstraZeneca's Crestor, and Zocor and Mevacor, sold by Merck & Co.

Source: Record, The; Bergen County, N.J.

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