Breast Cancer Vaccine Bid
Posted on: Thursday, 10 March 2005, 06:00 CST
SCIENTISTS could soon be testing a breast cancer vaccine on humans.
It helps the immune system to target a protein called mammaglobin- A, which is found in 80 per cent of breast tumours.
In mice, immune cells primed by the vaccine caused tumours with the protein to stop growing and then shrink.
US scientists made the vaccine from copies of the DNA sequence that makes mammaglobin-A.
Dr Thalachallour Mohan-akumar said: 'Mammaglobin-A is involved in breast development and secreted in breast milk, so we had to prove first that we could elicit an immune response to a protein that is in the body normally.'
Tests were carried out by injecting the vaccine into mice which were genetically engineered to have human-like immune systems.
Now clinical trials are planned in patients who are at very high risk of breast cancer or have had a relapse.
Source: Daily Record; Glasgow (UK)
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