June 17, 2008

Depomed Announces Allowance of Additional U.S. Patent Covering Gabapentin GR(R)

Depomed, Inc. (NASDAQ:DEPO) announced today that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for U.S. patent application number 10/280,309.

Paul B. Simboli, Depomed's director of Intellectual Property, noted that the patent contains claims directed to methods for treating neuropathic pain and claims related to methods for delivering compounds via specific dosage form technologies.

Carl A. Pelzel, Depomed's president and chief executive officer, added, "This additional patent and the 67 newly allowed claims significantly extend the patent portfolio around our two active Gabapentin GR programs, one of which is currently in a pivotal Phase 3 clinical trial for the treatment of postherpetic neuralgia, and another for the treatment of menopausal hot flashes which we expect to advance into Phase 3 later this year."

Subject to final issuance from the Patent and Trademark Office, the newly allowed claims are expected to expire in 2024, taking into account an anticipated patent term adjustment of at least 21 months. In addition to the allowed U.S. patent application, a corresponding patent has also been granted in Australia, and is pending in numerous other countries.

About Depomed

Depomed, Inc. is a specialty pharmaceutical company with two approved products on the market and other product candidates in its pipeline. The company utilizes its proven, proprietary AcuForm(TM) drug delivery technology to improve existing oral medications, allowing for extended, controlled release of medications to the upper gastrointestinal tract. Benefits of AcuForm-enhanced pharmaceuticals include the convenience of once-daily administration, improved treatment tolerability and enhanced compliance and efficacy. Glumetza(R) (metformin hydrochloride extended release tablets) is approved for use in adults with type 2 diabetes. Proquin(R) XR (ciprofloxacin hydrochloride) extended release tablets are approved in the United States for the once-daily treatment of uncomplicated urinary tract infections and will be marketed in the United States within the urology specialty by Watson Pharmaceuticals. Product candidate Gabapentin GR(R) is currently in clinical development for the treatment of neuropathic pain and for menopausal hot flashes. Additional information about Depomed may be found on its web site, www.depomedinc.com.

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