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New Technology May Prevent Vitamin B12 Deficient Seniors, Vegetarians and Anemics From Needing Injections

June 17, 2008

For those patients who receive the nearly 40 million intramuscular injections per year to treat their B12 deficiency, a new oral option may soon exist.

According to the National Institutes of Health, vitamin B12 deficiency can lead to a wide spectrum of conditions, such as anemia, dementia and reduced cognitive functioning. Vitamin B12 deficiency is a significant health issue. Nearly 40 percent of the U.S. population is B12 deficient (Tufts University, Boston). This includes a sizable number of patients who are severely deficient and are currently being treated. Further, a vast number of people are completely unaware they are B12 deficient and will eventually need treatment. Seniors and strict vegetarians are most at risk. Symptoms such as fatigue, constipation, loss of appetite and weight loss can occur in those who are deficient.

Currently, physicians rely on B12 shots for people with vitamin B12 deficiency because of the poor bioavailability of oral formulations. Past studies have shown that only approximately one percent of a vitamin B12 tablet gets absorbed in the bloodstream after traveling through the digestive track. Because so much of the vitamin is wasted, alternatives to effectively treat or protect against B12 deficiency are needed.

“Vitamin B12 is a perfect example of the successful application of our eligen(R) technology,” said Cristina Castelli, Ph.D., AAPS expert and lead researcher at Emisphere Technologies, Inc. “Our current studies have shown our oral solid formulation brings vitamin B12 absorption to a range of 7-30% without the discomfort of an invasive route of administration.”

Ms. Castelli and other project researchers will be at the AAPS National Biotechnology Conference to present and discuss their research with hundreds of pharmaceutical scientists from countries around the world.

Animal testing has been completed and researchers are now conducting human studies.

About AAPS

The American Association of Pharmaceutical Scientists (AAPS) is a professional, scientific organization of more than 13,500 members employed in academia, industry, government, and other research institutes worldwide. Founded in 1986, AAPS provides a dynamic international forum for the exchange of knowledge among scientists to serve the public and enhance their contributions to health. AAPS offers timely scientific programs, on-going education, information resources, opportunities for networking, and professional development.

Editor’s Note:

All abstracts presented at the AAPS National Biotechnology Conference are available upon request. To register for the meeting or to set up an interview with a pharmaceutical expert, please contact Tom Huddleston at 703-248-4744, HuddlestonT@aaps.org prior to June 22, or Amanda Rich at 305-573-9955, arich@golinharris.com. Registration is complimentary for members of the media. For the period of June 22 – June 25, call the AAPS Press Room on-site in Toronto at 416-585-3701.




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