Generex Biotechnology Expands Mayo Clinic Collaboration for Vaccine Studies; Preparations Underway for Clinical Trials in Melanoma Patients
WORCESTER, Mass., June 26, 2008 (PRIME NEWSWIRE) — Antigen Express, Inc. (www.antigenexpress.com), the wholly-owned immunotherapeutics subsidiary of Generex Biotechnology Corporation (Nasdaq:GNBT) (www.generex.com), has signed a second collaboration agreement with the Mayo Clinic (www.mayoclinic.com). Antigen Express previously entered into an agreement with the Mayo Clinic to work with Dr. Keith Knutson, a leader in the field of peptide vaccines in breast cancer. The current agreement focuses on advancing an immunotherapeutic vaccine for melanoma into the clinic with Dr. Svetomir Markovic, a distinguished translational researcher with expertise in melanoma trials.
Antigen Express has previously identified a novel peptide vaccine for melanoma and published its findings in an article titled, “Enhanced CD4+ T-Cell Response in DR4-Transgenic Mice to a Hybrid Peptide Linking the Ii-Key Segment of the Invariant Chain to the Melanoma gp100(48-58) MHC Class II Epitope,” in the Journal of Immunotherapy, volume 28, pages 352-358, 2005.
“We are excited to begin the process of moving this into the clinic with Dr. Markovic,” said Dr. Eric von Hofe, President of Antigen Express. “He is an outstanding investigator with whom we are fortunate to have the opportunity to work.”
The immunotherapeutic melanoma vaccine was constructed using the same technology as was employed for AE37, Antigen Express’s most advanced peptide vaccine currently in Phase II clinical trials in patients with breast cancer. The strategy is based on modifying fragments of a cancer-associated protein using proprietary methods to increase the antigen-specific stimulation of CD4+ T helper cells. The stimulation of T helper cells has been shown to be critical in achieving tumor immunity.
About Generex Biotechnology Corporation
Generex is engaged in the research, development, and commercialization of drug delivery systems and technologies. Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Company’s proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Company’s proprietary RapidMist(tm) device. The Company’s flagship product, oral insulin (Generex Oral-lyn(tm)), which is available for sale in Ecuador for the treatment of patients with Type-1 and Type-2 diabetes and which was approved for sale in India in October 2007, is in Phase 3 clinical trials at several sites around the world. For more information, visit the Generex website at www.generex.com.
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CONTACT: CEOcast, Inc. Gary Nash 212-732-4300 For Generex: American Capital Ventures, Inc. Howard Gostfrand 305-918-7000