Learn About the Stem Cell Markets
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Stem Cell Markets
http://www.reportlinker.com/p090979/Stem-Cell-Markets.html
A stem cell is an extraordinary type of cell that has the ability to self-renew for long periods of time and to differentiate into specialized cells under appropriate physiological or experimental conditions. Traditionally, stem cells have been classified as either embryonic, adult (tissue-specific or cord blood) stem cells. Recent understanding of stem cell biology may provide new approaches for the treatment of a number of diseases as well as tissue/organ injuries, including cardiovascular disease, neurological disease, musculoskeletal disease, diabetes and hematopoietic disorders. Stem cell fate is determined by both intrinsic regulators and the extra-cellular environment (niche), and their expansion and differentiation ex vivo are generally controlled by growing them in a specific configuration (monolayer or three-dimensional culture). This process, which is vital to enable stem cells to be used for therapeutic purposes, is called differentiation. Differentiation is a process involving unspecialized cells progressing to become specialized cells with restricted developmental potential. The purpose of this TriMark Publications report is to describe the specific market segments of the medical research space using stem cells for research and development (R&D) purposes. This study reviews all of the generally accepted analytical methods that are currently in use today for preparing and using stem cells. It examines the use of stem cells in developing new therapies for disease.
1. Overview
1.1 Statement of Report
1.2 Scope of the Report
1.3 Methodology
1.4 Executive Summary
2. Biology of Stem Cells
2.1 Scope of this Chapter
2.2 Basic Properties of Stem Cells and Their Classification
2.3 Differentiation of Stem Cells
2.3.1 Neural and Neuronal Differentiation
2.3.2 Cardiomyogenic Differentiation of ESCs
2.3.3 Differentiation of Mesenchymal Stem/Progenitor Cells
2.4 Self Renewal of Stem Cells
2.5 Dedifferentiation and Nuclear Reprogramming
2.6 Functional Proliferation of Adult Mature Cells
2.7 Nanog Promotes Transfer of Pluripotency After Cell Fusion
2.8 MicroRNAs in Stem Cell Development
2.9 Stem Cell Therapy
3. Market Analysis of the Stem Cell Space
3.1 Scope of this Chapter
3.2 The Overall Market Opportunity and Segmentation of the Total Stem
Cell Marketplace
3.3 Potential Stem Cell Commercial Applications
3.3.1 Cord Blood Stem Cells and Cord Blood Stem Cell Banking: Current Market Environment and Opportunity
3.4 Results of Primary Market Survey to Characterize Qualitative and Quantitative Trends in the Stem Cells Space
3.4.1 Characteristics of the Respondent Pool
3.4.2 Utilization of the Different Classes of Stem Cells
3.4.3 Quantitative Metrics of the Stem Cell Research Marketplace: Number of Experiments Performed in Research
3.4.4 Evolution of Research Activities with the Different Types of Stem Cells: Current Usage Trends and Usage in 12 to 18 Months
3.4.5 Types of Research Activities the End-User Community Performs with the Different Types of Stem Cells
3.4.6 Challenges Facing Stem Cell Researchers
3.4.7 Market Drivers and Research Questions Being Addressed in the Stem Cell Space
3.4.8 Summary of Challenges and Opportunities in the Stem Cell Space Based on TriMark’s Analysis
3.4.9 Unmet Product Needs in the Stem Cell Research Space and Licensing/IP Constraints
3.5 Competitive Landscape of the Stem Cell Marketplace
3.5.1 SWOT Analysis of the Major Stem Cell Market Segments
3.6 Market Size and Forecasts
4. Worldwide Landscape of Stem Cell Research
4.1 Scope of this Chapter
4.2 Global Embryonic Stem Cell Research
4.2.1 Top Research Institutions Worldwide in the Stem Cells Space and Global “Hot Spots” for Research and Therapeutics
4.3 Stem Cell Research in the U.S.
4.3.1 Proposition 71 in the State of California
4.4 Intellectual Property (IP) Landscape Surrounding Stem Cells
4.5 Who Will Finance Stem Cell Research?
4.5.1 U.S. Government Policy on Stem Cell Research
4.5.2 Current Federal Policy
4.5.2.1 Moral Issues Affecting the Policy
4.5.2.2 Significance and Requirement of Federal Funding
4.5.2.3 Implementing the Current Policy
4.5.3 International Law
4.5.3.1 Australia
4.5.3.2 U.K.
4.5.3.3 Canada
4.5.3.4 China
4.5.3.5 Germany
4.5.3.6 Switzerland
4.5.3.7 Japan
4.5.3.8 Israel
4.5.3.9 Singapore
4.5.4 Technological and Economical Disadvantage for U.S.
5. Therapeutic Areas and Research Programs in the Stem Cell Space
5.1 Scope of this Chapter
5.2 Therapeutic and Other Markets Addressed by Stem Cells
5.2.1 Hematopoietic Stem Cells (HSCs)
5.2.2 Stem Cell Therapeutics for Cardiac and Ischemic Diseases
5.2.3 Stem Cell Therapeutics for Type I Diabetes
5.2.4 Stem Cell Therapeutics for Orthopedic Diseases
5.2.5 Stem Cell Therapeutics for Neurological Disease
5.3 Off-the-Shelf Stem Cells Being Developed
6. Company Profiles
Appendix 1. Glossary of Terms in Stem Cell Biology
INDEX OF FIGURES
Figure 2.1: Derivation of Embryonic Stem Cells (ESCs) from the Inner Cell Mass of Blastocysts
Figure 2.2: Classification of Stem Cells: Embryonic Stem Cells Versus Adult Stem Cells
Figure 2.3: Somatic Cell Nuclear Transfer (SCNT)
Figure 3.1: Segmentation of the Stem Cell Marketplace Based Upon Commercial Offerings-Products and Services
Figure 3.2: Geographical Breakout of Stem Cell End-User Survey Respondents
Figure 3.3: Affiliation (Pharma, Biotech, Academic/University) of Stem Cell End-User Survey Respondents
Figure 3.4: Survey Respondents Are Studying Stem Cells or Using Stem Cells in Their Research
Figure 3.5: Length of Time Survey Respondent Pool Has Been Studying Stem Cells or Using Stem Cells in Its Research Activities
Figure 3.6: Utilization/Research with Different Stem Cell Types
Figure 3.7: Range of Number of Experiments Involving Stem Cells Conducted Per Week
Figure 3.8: Differences with Respect to Usage of Stem Cell Types
Figure 3.9: Research Dollars Spent Monthly on Research/Studies with Different Stem Cell Types
Figure 3.10: Growth of Research Spending in Various Segments of the Stem Cells Space (Defined by Stem Cell Type)
Figure 3.11: Growth in End-User Utilization of the Various Different Stem Cell Types
Figure 3.12: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells
Figure 3.13: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months
Figure 3.14: Broad Classification of Research Activities Being Performed with Stem Cells by Researchers
Figure 3.15: Current End-User Utilization Category of Adult Stem Cells (ASCs)
Figure 3.16: Current End-User Utilization Category of Human Embryonic Stem Cells (hESCs)
Figure 3.17: Current End-User Utilization Category of Human Cord Blood Stem Cells
Figure 3.18: Current End-User Utilization Category of Animal Stem Cells
Figure 3.19: Current End-User Utilization Category of Cancer Stem Cells
Figure 3.20: Challenges in the Study or Utilization of Adult Stem Cells (ASCs)
Figure 3.21: Challenges in the Study or Utilization of Human Embryonic Stem Cells (hESCs)
Figure 3.22: Challenges in the Study or Utilization of Human Cord Blood Stem Cells
Figure 3.23: Challenges in the Study or Utilization of Animal Stem Cells
Figure 3.24: Challenges in the Study or Utilization of Cancer Stem Cells
Figure 3.25: Top Unmet Needs in Commercial Products in the Stem Cell Research Space
Figure 3.26: The U.S. Stem Cell Therapy Market Sales, 2005-2016
Figure 4.1: Stem Cell Research Worldwide
INDEX OF TABLES
Table 2.1: The Different Types of Stem Cells and Their Properties
Table 2.2: Adult Stem Cell (ASC) Differentiation Properties
Table 3.1: Characteristics of Different Stem Cell Types and Associated Market Opportunity
Table 3.2: Segmentation of the Stem Cell Market by Type/Lineage of Stem Cells
Table 3.3: Selected Cord Blood Banks in the U.S.
Table 3.4: Selected Companies in the Cord Blood Stem Cell Technology and Therapeutics Development Space
Table 3.5: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells
Table 3.6: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months
Table 3.7: Market Share of Companies/Institutions Offering Different Stem Cells to Researchers
Table 3.8: Market Share of Companies/Institutions Offering Reagents for Stem Cell Research
Table 3.9: The U.S. Stem Cell Therapy Market Forecast, 2005-2016
Table 3.10: The World Market for Stem Cell Products and Services, 2005-2012
Table 4.1: Major Milestones in Stem Cell Research and Associated Timeline, 1981-2008
Table 4.2: Selected Stem Cell Hot Spots Worldwide Administering Non-FDA Approved Stem Cell Therapeutic Regimens
Table 4.3: NIH Funding of Stem Cell Research in the U.S., 2004-2009
Table 4.4: Snapshot of the Current Key Stem Cell Patents
Table 4.5: Stem Cell Derivations
Table 5.1: Estimate of Potential Market Opportunity for Stem Cell-based Therapeutics
Table 5.2: Autologous Versus Allogeneic Cell Therapy
Table 5.3: Diseases Treated with HSC Transplantation Today
Table 5.4: HSC Sources and Their Properties
Table 5.5: Stem Cell Therapeutics for Hematological Diseases in Development Table 5.6: Stem Cell-based Therapeutics for Cardiac and Ischemic Diseases in Development
Table 5.7: Stem Cell-based Therapeutics for Vascular Diseases in Development
Table 5.8: Stem Cell Therapeutics for Type I Diabetes in Development
Table 5.9: Stem Cell Therapeutics for Orthopedic Disease in Development
Table 5.10: Stem Cell Therapeutics for Neurological Disease in Development
Table 5.11: Segmentation of the Allogeneic Cell Therapy Market
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Stem Cell Markets
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