July 17, 2008
Hollis-Eden Initiates Phase II Diabetes Trial
Hollis-Eden Pharmaceuticals has started a Phase II clinical trial with its oral drug candidate Triolex in type 2 diabetes patients. The company also announced that it is expanding the number of clinical sites to accelerate enrollment.
The Phase II, double-blinded placebo controlled 12-week dosing trial will enroll approximately 90 patients who are stable on metformin treatment only, the current first-line therapy for type 2 diabetes, with a hemoglobin A1c (HbA1c) level in excess of 7.5%.
Richard Hollis, chairman and CEO of Hollis-Eden, said: "Since Triolex targets inflammation as an underlying cause of type-2 diabetes, the compound, if successfully developed, holds the promise to become a first-in-class treatment option with competitive advantages over existing therapies in the marketplace.
"In addition, since we believe Triolex is acting as a novel anti-inflammatory, the compound may have benefit in other diseases as well. Accordingly, in this Phase II study we will be evaluating the ability of the compound to affect a number of other markers associated with low-grade inflammation."