July 25, 2008
Scientists Find Key to Statin Side Effect
Scientists may have found a way to test for and possibly avoid the most serious side effect of cholesterol-lowering statin drugs, one of the top-selling medicines in the world.
In rare cases, statins can cause muscle pain and weakness. Researchers have identified a genetic variation that seems to predict more than half of these cases. People on statins who have the variant were five to 17 times more likely to develop muscle problems, a serious side effect that can lead to muscle breakdown, kidney failure and death.
The finding raises hope that a test could be developed to screen heart patients to find out who is at greatest risk. Normally, muscle weakness caused by statins affects 1 out of 10,000 patients a year.
"It could become a very simple check," said Rory Collins of the University of Oxford, who co-wrote the study published in today's New England Journal of Medicine.
But doctors say having this knowledge doesn't mean the millions taking statins should be tested, especially those who are having no problem.
"I would recommend extreme caution in testing for this," said Dr. James Stein, a University of Wisconsin-Madison cardiologist who had no role in the research. "It could potentially lead to people not taking lifesaving drugs just because there's an excess risk" of a side effect.
Statins are mostly prescribed to prevent heart attacks in people with clogged arteries and work by dramatically lowering LDL or "bad cholesterol."
Last year, global sales for statins topped $14.8 billion, according to health care research firm IMS Health.
Originally published by Associated Press.
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