Early Onset Gene for Inflammatory Bowel Diseases Identified

Early onset gene for inflammatory bowel diseases identified WASHINGTON, Sept. 3 (Xinhua) — A study of Crohn’s disease and ulcerative colitis in children has identified a gene that influences whether children get these diseases early in life, and points to a potential new target for treatment.

The findings of the international team that performed the study were published online this week by the journal Nature Genetics.

They identified the gene TNFRSF6B, whose activity was associated with the degree of inflammation in the colon.

Crohn’s disease and ulcerative colitis are chronic inflammatory diseases that affect the intestines. In ulcerative colitis, the inner lining of the colon is inflamed, while in Crohn’s disease the inflammation extends deeper into the intestinal wall and can involve both the small and large intestine.

While several genes that influence susceptibility to the two diseases have been found previously, this study is the first to focus on inflammatory bowel disease with childhood onset, says co- first author Subra Kugathasan from Emory University.

“Our novel candidate gene is in the same inflammatory pathway as some other susceptibility genes, so it may represent an accessible target for treatment,” Kugathasan says.

Both genetics and the environment have an effect on the risk of getting inflammatory bowel disease. If one identical twin suffers from Crohn’s disease, the other has a 60 percent probability of getting it too. However, the incidence of disease has drastically increased over the last half century, suggesting a key role of the environment in disease development. Smoking is an environmental factor that is particular strong in increasing the risk of Crohn’s disease.

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