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Get a Deep Insight into the World Human Vaccines Market

September 18, 2008

Reportlinker.com announces that a new market research report related to the Infectious diseases industry is available in its catalogue.

World Human Vaccines Market

http://www.reportlinker.com/p092575/World-Human-Vaccines-Market.html

This report analyzes the worldwide markets for Human Vaccines in Millions of US$. The major product segments analyzed are Prophylactic Vaccines (Pediatric Prophylactic Vaccines, & Adult Prophylactic Vaccines), and Therapeutic Vaccines. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East and Latin America. Annual forecasts are provided for each region for the period of 2001 through 2015. A ten-year historic analysis is also provided for these markets with annual market analytics. The report profiles 164 companies including many key and niche players worldwide such as ALK – Abello A/S, Acambis PLC, Bavarian Nordic A/S, Crucell N.V., CSL Ltd., GlaxoSmithKline PLC, GlaxoSmithKline Biologicals S.A, Medimmune, Inc, Merck & Company, Inc., Novartis Vaccines & Diagnostics, Inc., Sanofi-Aventis S A, Sanofi-Pasteur SA, Sanofi Pasteur, Inc., Shanta Biotechnics Ltd., Vaxin, Inc., and Wyeth. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

 HUMAN VACCINES MCP-1176  A GLOBAL STRATEGIC BUSINESS REPORT  CONTENTS  I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS  Study Reliability and Reporting Limitations I-1  Disclaimers I-2  Data Interpretation & Reporting Level I-2  Quantitative Techniques & Analytics I-3  Product Definitions and Scope of Study I-3  Prophylactic Vaccines I-3  Therapeutic Vaccines I-3  II. EXECUTIVE SUMMARY  1. Market Overview & Outlook II-1  Market Dynamics II-1  Global Human Vaccine Market: A Snapshot II-2  Vaccine Pricing: The Developed - Developing Divide II-2  Overview in the Recent Context II-2  Historical Perspective II-3  Successful Vaccine Introductions in the Past II-3  Looking Ahead II-3  Key Markets II-4  Competitive Scenario II-4  World's Leading Producers II-4  Table 1: Leading Players in the Worldwide Human Vaccines  Market (2005): Percentage Breakdown by Value Sales for  Sanofi-Aventis, GlaxoSmithKline, Wyeth, Merck, and Others  (includes corresponding Graph/Chart) II-5  ALK- The Global Leader in Allergy Vaccines II-5  Table 2: Leading Players in the Worldwide Allergy Vaccines  Market (2005 & 2006): Percentage Breakdown by Value Sales  for ALK-Abello, Stallergenes, Allergopharma, and Others  (includes corresponding Graph/Chart) II-5  2. Product Overview II-6  Introduction to the Concept of Immunity II-6  Role of Vaccines in Strengthening the Immune System II-6  Vaccines and Immunotherapy II-7  Historical Overview of Vaccines II-7  How it Began II-7  So Far So Good II-8  Contribution of Animal Research to Vaccine Production II-8  Types of Vaccines II-9  Live, Attenuated Vaccines II-10  Combination Vaccines II-11  Killed or Inactivated Vaccines II-11  DNA & Recombinant DNA Vaccines II-11  Toxoids II-12  Cellular Fractions II-12  Conjugate Vaccines II-12  Subunit Vaccines II-13  Passive Immunization II-13  Prophylactic Vaccines II-13  Prevention Better than Cure II-13  Prophylactic Pediatric Vaccines II-13  Vaccination Over the Years II-14  A Mature Market II-14  Challenges for Pediatric Vaccines Market II-15  BCG Vaccine II-15  Growth Boosting Factors for TB Vaccines II-16  Demand Restraining Factors for TB Vaccines II-16  Major Issues to be addressed in the TB Vaccine Market II-16  Table 3: TB Vaccines Market Worldwide: Annual Sales for  2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-17  Hemophilus Influenza Type B Vaccine II-17  Hib and Combination Vaccines by Producer II-17  Table 4: Pediatric Haemophilis Influenza B Vaccine Market in  the US and Europe: Annual Sales for 2000-2005 (In US$  Million) (includes corresponding Graph/Chart) II-18  Table 5: Pediatric Haemophilis Influenza B Vaccine Market in  the US: Annual Sales for 2000-2005 (In Million Doses)  (includes corresponding Graph/Chart) II-18  Diphtheria/Tetanus/Pertussis Vaccines II-18  DTP, DTaP, and Combination Vaccines Offered by Major  Producers in US II-19  Table 6: Leading Players in the US DTP and DTaP Vaccines  Market (2003-2005): Percentage Breakdown by Value Sales for  Sanofi Pasteur, Wyeth, GlaxoSmithkline, and Others (includes  corresponding Graph/Chart) II-19  Table 7: DTP and DTaP Vaccines Market in the US: Annual  Sales for 2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-20  Table 8: DTP Vaccine Market in Europe: Annual Sales for  2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-20  Hepatitis A Vaccine II-20  Hepatitis B Vaccine II-20  Hepatitis B Epidemiology II-21  Table 9: Hepatitis B Vaccines Market in US and Europe:  Annual Sales for 2000-2005 (In US$ Million) (includes  corresponding Graph/Chart) II-21  Measles/Mumps/Rubella Vaccines II-21  Table 10: Measles-Mumps-Rubella (MMR) Vaccine in US and  Europe: Annual Sales for 2000-2005 (In US$ Million)  (includes corresponding Graph/Chart) II-22  Table 11: Measles-Mumps-Rubella (MMR) Vaccine Market in the  US: Annual Sales for 2000-2005 (In Millions of Doses)  (includes corresponding Graph/Chart) II-22  Rotavirus Vaccines II-23  Polio Vaccines II-23  Table 12: Polio Vaccine Market in Europe: Annual Sales for  2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-23  Table 13: Polio Vaccines Market in the US: Annual Sales for  2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-24  Table 14: Polio Vaccine Market for Both Vaccine Types in the  US: Annual Sales for 2000-2005 (In Million Doses) (includes  correspondingGraph/Chart) II-24  Table 15: Polio Vaccine Market for Both Vaccine Types (OPV  and IPV) in the US in Percent of Doses from 2000-2005  (includes corresponding Graph/Chart) II-24  Varicella Vaccine II-25  Table 16: Varicella Vaccine Market in the US and Europe:  Annual Sales for 2000-2005 (In US$ Million) (includes  corresponding Graph/Chart) II-25  Table 17: Varicella Vaccines Market in the US: Annual Sales  for 2000-2005 (In Million Doses) (includes corresponding  Graph/Chart) II-26  Need for Combination Vaccines II-26  Prophylactic Adult Vaccines II-27  Favorable Market Growth II-27  Hepatitis A Vaccine II-27  Hepatitis B Vaccines II-28  Key Issues Affecting the Adult Hepatitis Vaccines Market II-29  Cholera Vaccine II-29  Hepatitis A/Hepatitis B Vaccine II-29  Japanese Encephalitis Vaccines II-30  Influenza Vaccines II-30  Table 18: Global Flu Vaccines Market (2005): Percentage  Breakdown by Value Sales for the US, EU, and Rest of the  World (includes corresponding Graph/Chart) II-31  Table 19: Global Flu Vaccines Market (2005): Percentage  Breakdown by Volume Sales for Sanofi Pasteur, Chiron, GSK  and Others (includes corresponding Graph/Chart) II-31  Table 20: Rate of Influenza Vaccine Consumption Among Target  Groups (includes corresponding Graph/Chart) II-31  Table 21: Adult Influenza Vaccines Market Worldwide: Annual  Sales for 2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-32  Growth Boosting Factors for Influenza Vaccines Market II-32  Key Issues Affecting Influenza Vaccines Market II-32  Age-Driven Strategies Drive Target Market for Influenza  Vaccines II-32  Healthcare Professionals Increase Target Market for  Influenza Vaccines II-33  Lyme Disease Vaccine II-33  Pneumococcal Disease Vaccines II-33  Meningococcal Vaccines II-34  Rabies Vaccines II-34  Table 22: Rabies Vaccine Market Worldwide: Annual Sales for  2000-2005 (In US$ Million) (includes corresponding  Graph/Chart) II-35  Typhoid Vaccine II-35  Yellow Fever Vaccine II-35  Need for Additional Vaccines II-35  Therapeutic Vaccines II-37  DNA Holds the Key II-37  Huge Potential for Protein Based Vaccines II-38  Cancer Vaccines II-38  Human Papillomavirus (HPV) Vaccine II-38  Breakthroughs in Cancer Vaccine Market II-38  Factors Affecting the Market for Cancer Vaccines II-39  Vaccine for AIDS II-39  What is AIDS? II-39  Global Statistics II-39  Table 23: Worldwide HIV/AIDS Estimates - 2007 (includes  corresponding Graph/Chart) II-40  Table 24: Worldwide HIV & AIDS Incidences (2007): A  Regional Breakdown for Living and Newly Infected Cases  (includes corresponding Graph/Chart) II-40  Table 25: Worldwide HIV & AIDS Prevalence Rate in Adults  Aged between 15 and 49 Years for the Year 2007 (includes  corresponding Graph/Chart) II-41  Asia-Pacific II-41  Central Asia & Eastern Europe II-42  Commonwealth of Independent States (CIS) II-42  Latin America (Including the Caribbean Islands) II-42  Sub Saharan Africa II-42  North Africa & the Middle East II-43  Developed Regions and High Income Countries II-43  United States II-43  Table 26: New HIV Infection Cases among Men in the US  (2006): Percentage Breakdown by Mode of Infection  (includes corresponding Graph/Chart) II-43  Table 27: New HIV Infection Cases in the US (2006):  Percentage Breakdown by Racial/Ethnic Groups (includes  corresponding Graph/Chart) II-44  Table 28: New HIV Infection Cases among Women in the US  (2006): Percentage Breakdown by Mode of Infection  (includes corresponding Graph/Chart) II-44  Development of Treatment Options II-44  Categories of Vaccines for AIDS II-44  HIV Vaccines in Development II-45  HIV Vaccines (Prophylactic/Therapeutic) Under Development  (2007) by Key Manufacturers II-45  Malaria Vaccine II-45  Therapeutic Vaccines Against Infectious Diseases: The  Challenges II-46  Melanoma: Prospects for Treatment II-46  Vaccines for Melanoma in Development II-46  Autoimmune Diseases II-46  How Do Autoimmune Diseases Occur II-46  Types of Autoimmune Diseases II-46Need for Developing Autoimmune Therapeutic Vaccines II-46  Travel Vaccines: Opportunities II-47  SARS - Need for Urgent Solutions II-47  Vaccinations Recommended for Travel to High-Risk Areas II-48  Mechanisms for Vaccine Delivery II-48  Edible Vaccines II-49  Oral Vaccines II-50  Tablet Based Vaccines II-50  Mucosal Delivery II-50  Transdermal Patch Delivery II-50  3. Market Trends & Issues II-51  Newer Vaccines in Pipeline to Cheer Up Pharma Companies II-51  Threat of Pandemic Rejuvenates Vaccine Market II-51  Influenza Vaccines On a Growing Spree II-51  Influenza Market Faces Several Challenges II-51  Economic Factors Hamper Optimal Vaccine Development and Delivery II-52  Increasing Need for Vaccine Promotion in the Developing Regions II-52  Changing Vaccine Needs II-52  DNA Vaccines: Engineering Growth II-53  AIDS Vaccine: Long Road Ahead II-54  Noninjectable Vaccines: Gain Without Pain II-54  Need for a Human Vaccine for Leishmaniasis II-55  Conjugate Vaccines: A Technological Innovation II-55  Need For a New TB Vaccine II-55  Companies Involved in TB Vaccine Research II-56  Religious Concerns Over Immunizing Young Girls II-56  Changing Travel Patterns Increase Demand for Hepatitis B Vaccine II-56  DTaP Vaccines Approved for Booster Vaccination II-56  Advances in Biotechnology Spearheading Vaccines' Growth II-56  BioWarfare: Threat Perception and Preparedness II-57  Overview of Potential Bio-Terrorist Agents II-57  Smallpox (Variola Major) II-57  Anthrax (Bacillus Anthracis) II-58  Plague (Yersinia Pestis) II-58  Botulism (Clostridium Botulinum) II-58  Tularemia (Francisella Tularensis) II-58  Market Concerns II-58  Safety Factor II-58  Development Delays II-59  Storage Problems II-59  Perfluorocarbons as Alternative to Overcome Storage Problems II-59  Costs II-59  Standards for Vaccine Safety and Quality II-60  4. Distribution Channels II-61  5. Technological Developments II-62  Applying Gene Therapy to Develop Therapeutic Solutions II-62  Research and Trials of AIDS Vaccines II-62  Ongoing R&D for AIDS Vaccines II-62  International AIDS Vaccine Initiative (IAVI) II-62  Cancer II-63  Cancer Type and Area Effected II-63  Immunotherapies for Cancer II-63  Drugs for Cancer II-63  Issues Effecting the Development of Commercially Viable  Cancer Vaccines II-64  Frequency of Vaccination II-64  Growth Boosters in the Cancer Vaccines Market II-64  Cancer Vaccines Available II-65  Select Cancer Vaccines in Trial Stage II-65  Other Vaccines for Cancer II-66  Application of Botulinum Toxin as Delivery Mechanism for Oral  Vaccines II-66  6. Clinical Trials II-67  AVANT's Single-Dose Oral Ty800 Vaccine Meets Key Endpoints II-67  Emergent BioSolutions' Typhoid Vaccine Completes Final Phase  II Clinical Trial II-67  Antigenics Announces Positive Data on Phase-I Study of ACAM-  FLU-ATM Vaccine II-67  Bavarian Nordic's IMVAMUNE(R) Post-Exposure Vaccination  Demonstrates Protection Against Fatal Poxvirus Infection II-68  BSU Scientists to Commence Human West Nile Vaccine Development  Project II-68  Intercell Concludes First Phase Clinical Studies of IC31(R)  Adjuvanted Influenza Vaccine II-68  Protherics Commences Phase 2 Angiotensin Vaccine Study II-69  CSL Biotherapies Files BLA for Influenza Vaccine II-69  Orchestra Therapeutics Abandons Development of HIV Vaccine II-69  AlphaVax Concludes Phase I Clinical Trial of Flu Vaccine II-70  AVANT Presents Preclinical Data on Enteric Vaccine II-70  Baxter Declares Results of Seasonal Flu Vaccine Candidate Trial II-70  IDM Pharma Announces Interim Data of Phase II Clinical Trials  of Lung Cancer Vaccine II-71  Novavax Announces Developments in Discovery Program II-71  Acambis Pioneers Testing of West Nile Virus Vaccine in Grown Ups II-72  Acambis Initiates Test of single-dose JE vaccine in India II-72  AVAX Technologies Initiates Phase 3 Clinical Trial For M-Vax II-72  LigoCyte Pharmaceuticals Begins Clinical Testing of Norovirus  Vaccine II-72  Alphavax Initiates Clinical Testing for Flu and CMV Vaccines II-73  Sanofi Pasteur Begins Phase 2 Testing of New Influenza Vaccine II-73  Antigenics Reveals the Preliminary Data of Clinical Trial of  Oncophage(R) II-74  Baxter Reveals Phase I/II Clinical Trial Results of H5N1  Pandemic Vaccine II-74  Crucell and AERAS Initiates Tuberculosis Vaccine Clinical Trial II-74  DOR BioPharma Announces Phase I Results of RiVax(TM) II-74  GlaxoSmithKline Starts Clinical Trials to Test H5N1 Pandemic  Flu Vaccines II-74  MedImmune Initiates Phase I Clinical Trial of Avian H5N1 Vaccine II-75  MedImmune Reveals Results of Phase 3 Study for CAIV-T II-75  MedImmune Initiates Second Phase 1 Study with MEDI-534 II-75  Sanofi Pasteur Initiates First Clinical Trial of Cell Based  H7N1 Vaccine II-75  Therion Biologics Completes Enrollment for Phase III trials of  PANVAC-VF II-75  ViRexx Finishes the Treatment in Phase I Study of HepaVaxx B  Vaccine II-76  Antigenics Begins Phase I Clinical Trial of AG-707 II-76  Positive Results in Novavax's Pandemic Influenza Vaccine Pre-  clinical Trials II-76  Trials Reveal H5N1 Pre-Pandemic Vaccine of Sanofi Pasteur  Effective II-76  PowderMed Reveals Reveals for Phase 1 Trials for Influenza  Vaccine II-76  Phase II clinical trials of China's hepatitis B vaccine II-76  7. Research Breakthroughs II-77  Findings Prove New Nose-Spray Vaccines Effective II-77  Large Doses of H5N1 Influenza Vaccine Appears Effective II-77  New Vaccine Technology to Prevent TB II-77  HPV Vaccine to Help Prevent Cervical Cancer II-77  Scientists Develop H7N1 Avian Influenza Vaccine II-77  Human H5N1 Vaccine Developed by Central Hygiene and  Epidemiology Institute II-78  8. Product Development II-79  Nabi Biopharmaceuticals to Develop NicVax Vaccine for Reducing  Nicotine Effects II-79  GenPhar Develops Highly Effective Tetravalent Dengue Vaccine II-79  Iomai Commences the Development of Prophylactic Traveler(TM)s  Diarrhea Vaccine II-79  Biological Immunological to Produce and Sell r-Hepatitis B  Vaccine II-79  Thailand Researchers Commence the Development of Human Bird  Flu Vaccine II-79  USV to Commercialize Typhoid Vaccine II-79  9. Product Launches II-80  GlaxoSmithKline to Introduce Five Key Medicines for Oncology II-80  FFF Enterprises Unveils My Flu Vaccine Network II-80  ALK-Abello Introduces GRAZAX(R) Anti-Allergy Vaccine II-80  Novartis Unveils Influenza Virus Vaccine Fluvirin(R) II-81  Wyeth Introduces Latest 7-in-1 Pneumococcal Conjugate Vaccine II-81  Intervet Releases Arnhem, a Prototype of Avian Influenza Vaccine II-81  Shantha Launches 'Jencevac' Brain Fever Vaccine II-81  Wockhardt and Zhejiang Introduces New Hepatitis-A Vaccine II-81  GSK Introduces Rotarix(R) Vaccines for Infants II-82  Sinovac Biotech Introduces Bilive(TM) II-82  10. Recent Industry Activity II-83  Emergent BioSolutions Acquires Group of Anthrax Monoclonal  Antibodies from AVANIR II-83  China Biopharma and BKXPC Enter into Agreement II-83  Encorium Signs Contract with Protherics for Phase 2 Trial of  ATV for Hypertension II-83  GenPhar to Establish Vaccine Production Plant in South Carolina II-84  Intercell Partners SSI and Sanofi Pasteur to Further Develop  TB Vaccine II-84  Intercell and PATH Malaria Vaccine Initiative Form New  Partnership for Malaria Vaccine II-84  Intercell Receives Manufacturer's License for Production of JE  Vaccine II-84  GSK Receives US FDA Approval for ROTARIX(R) Rotavirus Vaccine II-85  Dynavax and Merck & Co Announce Clinical Hold of HEPLISAV  Vaccine Trial II-85  Pharmexa and Ichor Enter into Co-Development Agreement for  Multiple DNA Vaccines II-86  Crucell Enters into Exclusive Development Agreement with Wyeth  Pharmaceuticals II-86  Crucell and Sanofi Ink an Agreement for Advanced Anti-Rabies  Biologicals II-86  FDA Confers Priority Designation for Supplemental Application  for GARDASIL (R) II-87  Sanofi Submits a European Marketing Approval Application for  First Influenza Vaccine II-87  IVT Signs an MoU to Take Over Immunotope II-88  Oxford BioMedica Takes Over Oxxon Therapeutics II-88  DND Issues RFP for acquisition of MVA-based smallpox vaccine II-88  GlaxoSmithKline Acquires Reliant Pharmaceuticals II-88  GSK Acquires Praecis Pharmaceuticals II-89  Berna Biotech Divests Stake in Pevion Biotech II-89  GeoVax Signs a Private Placement Agreement with Pure Capital II-89  Crucell Inks a Research License Agreement with ISU ABXIS of Korea II-89  China Biopharma Concludes Capital Funding to ZT Biotech II-89  Crucell and Acambis Ink a Licensing Agreement for PER. C6 (R)  Technology II-90  Novartis and Intercell Join Hands to Advance Vaccine Programs II-90  Serum Institute and Akorn Ink MoU for Vaccine  Commercialization in US Market II-90  Merck Plans to Establish a Human Vaccine Facility in Ireland II-91  Schering-Plough Acquires Organon Bio Sciences II-91  Intas Biopharmaceuticals Enters into Collaboration Agreement  with Virionics II-91  Oxxon Therapeutics Starts U.S. Operation II-91  GenPhar and ImmuneRegen Enter into Research Partnership II-92  Intercell Submits BLA for JE Vaccine to US FDA II-92  AVANT and Select Vaccines Enter into R&D Partnership II-92  AVAX Enters into Agreement with Cancer Treatment Centers of  America II-93  CSC's DVC and Baxter Receive Contract Modification from U.S. HHS II-93  DOR BioPharma Enters into CRADA with Walter Reed Army Institute II-94  Dynavax and Merck to Enter into Partnership to Develop  Hepatitis B Vaccine II-94  Emergent BioSolutions Commences Delivery of BioThrax(R) to US  Health Department II-94  Maxygen and Sanofi Pasteur sign License Agreement II-95  Beijing Public Health Bureau Enters into Purchase Agreement  with Sinovac II-95  Novartis Wins US Government Contract for Developing Antigen  Technology II-95  MedImmune Announces Licensing of Reverse Genetics Technology  to GlaxoSmithKline II-96  MedImmune Wins US Government Contract II-96  MedImmune and Human Genome Sciences Sign Lease Agreement II-97  Acambis Announces Signing of Collaboration Agreement withSanofi Pasteur II-97  Acambis Announces JE Partnership Agreement with Sanofi Pasteur II-97  Crucell Procures Major Patent for Influenza Vaccine Production II-98  CSL Receives FDA Approval for Influenza Virus Vaccine II-98  GlaxoSmithKline Inks Contract with UK Government II-98  Merck & Co., Inc. and Dynavax to Jointly Develop Hepatitis B  Vaccine II-99  Sanofi Pasteur Wins Contract to Design, Retrofit and Maintain  Influenza Vaccine Unit II-99  Sanofi Pasteur Completes Construction of Influenza Vaccine  Production Unit II-99  Amgen Acquires Abgenix II-100  Pfizer Acquires PowderMed II-100  CancerVax and Micromet Merge to Establish Micromet, Inc. II-100  Novartis Acquires Chiron II-100  Dynavax Takes Over Rhein Biotech II-100  AnGes and Vical Ink Collaborative Agreement II-101  GeoVax Merges with Dauphin II-101  Hawaii Biotech and Avantogen Merge to Form New Entity II-101  CytoDyn Acquires Advanced Influenza Technologies II-101  Emergent BioSolutions Acquires VIVACS II-101  Acambis Divests Berna Business to Crucell II-101  Novavax Inks an Agreement with Bharat Biotech to Develop Avian  Flu Vaccine II-101  Aeras Receives License for Developing and Distributing  Tuberculosis Vaccine II-102  Acambis to Supply Smallpox Vaccine to CDCP II-102  AlphaVax and Wyeth Enhance Existing Licensing Agreement II-102  Baxter Enters into a Contract to Supply Pandemic Influenza  Vaccine II-102  Sanofi Pasteur Signs Stockpile Contract with the US Government II-102  Crucell Licenses PER.C6(R) Technology to ADImmune Corporation II-103  Baxter Wins Stockpile Production Contract for H5N1 from the NHS II-103  Crucell Earns NIH Contract to Develop HIV Vaccine II-103  Novartis Secures Stockpile Supply Contract from the US Government II-103  Novartis Signs Distribution Agreement with Intercell II-103  GSK Receives Stockpile Supply Contract for Fly Pandemic from  the HHS II-104  GSK Signs H5N1 Antigen Influenza Vaccine Contract with  Switzerland II-104  DOR BioPharma Forms Alliance to Develop Ricin Vaccine II-104  Nobilon and NVI to Jointly Develop RSV Vaccine II-105  SciGen and OctoPlus Join Forces to Develop Hepatitis B Vaccine  Delivery II-105  AlphaVax Receives Patent for Alphavaccines Manufacturing Process II-105  IVI Receives Funds for Cholera Vaccine Development Program II-105  Novavax Forms Strategic Alliance with US-based, PacificGMP II-105  Sanofi Pasteur Enters into Partnership with PDVI II-106  MedImmune Inks a Cooperative R&D Agreement with NIAID II-106  MedImmune Bags a Five-Year HHS Contract II-106  Novavax Enters into a Cooperative Research Agreement with CDC II-106  GlaxoSmithKline Establishes New Vaccine Manufacturing Facility II-107  GenPhar Extends R&D Contract with NMRC II-107  Medlmmune Files for INDA with FDA for a New Influenza Vaccine II-107  Rotarix(TM) Vaccines Receives European Approval II-107  Merck's GARDASIL(R) Receives FDA Approval II-108  CDC Adds Merck's GARDASIL(R) Under its VFC Category in the US II-108  Medlmmune Submits sBLA to the FDA Refrigerator-Stable  Influenza Vaccine II-108  Medlmmune Submits sBLA to the FDA for Expanded Label for CAIV-T II-108  Medlmmune Receives FDA Approval for the Use of Reverse  Genetics Technology II-108  Vivalis Starts a New Plant in France to Produce Viral Vaccines II-108  Fiocruz Provides Yellow-Fever Vaccine to Peruvian Government II-109  Merck Receives FDA Approval for Zostavax Vaccine II-109  The US Health and Human Services Department Awards Grant to  Pharma Companies II-109  GlaxoSmithKline Expands License and Supply Agreement with  Antigenics II-109  GlaxoSmithKline Applies for Approval for Cervical Cancer Vaccine II-109  Omnia Biologics Signs Deal with Aeras Global TB Vaccine  Foundation II-109  Aeras Alliances with Dutch Scientific Organizations to Develop  Latest TB Vaccines II-110  Embrex, Shenzhen, and P.R. China Team Up for Manufacturing  Influenza Vaccine II-110  Health Canada Grants Approval to Merck's RotaTeq II-110  HepaLife Technologies Receives License for Technology from MSU II-110  Hindustan Latex Ties-up with Bharat Biotech for Marketing  Vaccines II-110  Emergent BioSolutions and Sanofi Pasteur Sign Agreement II-110  USV and BCIL Enter into Agreement II-111  GenVec Receives Fifth-Year Extension of Contract from NIAID II-111  Inovio Joins Hands with Tripep to Develop Hepatitis C Vaccine II-111  Novavax and Bharat Biotech Form Alliance to Develop Pandemic  Flu Vaccine II-111  Panacea Biotech Joins Hands with NVI to Create Polio Vaccine II-112  Immune Response Ties Up with Accelsiors for Trial of NeuroVax  Vaccine II-112  Nordic Vaccine Joins Forces with Ace BioSciences to Develop  Efficient Vaccines II-112  Eisai Partners with DNAVEC to Develop New Vaccine II-112  ViRexx Partners with DRDC to Develop Biodefence Vaccines II-112  Biovirx Teams Up with IDT to Reintroduce Vaccine for Infants II-113  LG Life Sciences Enters into Agreement with Sinovac II-113  MediGene Awards Licenses to Virionics for CVLP Vaccine Program II-113  FluLaval Influenza Vaccine Receives FDA Approval II-113  Merck Applies for Approval to Market Gardasil in China II-114  Bio-Bridge Establishes New Vaccine Facility in China II-114  SIIL Established the First-ever Biotech SEZ in India II-114  Aeras Foundation Establishes New Laboratory for TB Vaccine II-114  China Biopharma Distributes Flu Vaccine in China II-114  ViroPro Founds New Subsidiary for Developing Medicinal Vaccines II-114  Glaxosmithkline Acquires Corixa Corporation II-115  GSK Acquires ID Biomedical II-115  Pharmexa Acquires GemVax II-115  11. Focus on Select Global Players II-116  ALK - Abello A/S (Denmark) II-116  Acambis PLC (UK) II-116  Bavarian Nordic A/S (Denmark) II-116  Crucell N.V. (The Netherlands) II-117  CSL Ltd. (Australia) II-118  GlaxoSmithKline PLC (UK) II-118  GlaxoSmithKline Biologicals S.A (Belgium) II-120  Medimmune, Inc. (USA) II-120  Merck & Company, Inc. (USA) II-120  Novartis Vaccines & Diagnostics, Inc. (USA) II-121  Sanofi-Aventis S A (France) II-121  Sanofi-Pasteur SA (France) II-122  Sanofi Pasteur Inc. (USA) II-122  Shantha Biotechnics Ltd. (India) II-123  Vaxin, Inc. (USA) II-123  Wyeth (USA) II-124  12. Global Market Perspective II-125  Table 29: World Recent Past, Current & Future Analysis for  Human Vaccines by Geographic Region - US, Canada, Japan,  Europe, Asia-Pacific (excluding Japan), Latin America and Rest  of World Markets Independently Analyzed with Annual Sales  Figures in US$ Million for Years 2001 through 2010 (includes  corresponding Graph/Chart) II-125  Table 30: World Long-term Projections for Human Vaccines by  Geographic Region - US, Canada, Japan, Europe, Asia-Pacific  (excluding Japan), Latin America and Rest of World Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2011 through 2015 (includes corresponding  Graph/Chart) II-126  Table 31: World Historic Market Review for Human Vaccines by  Geographic Region - US, Canada, Japan, Europe, Asia-Pacific  (excluding Japan), Latin America and Rest of World Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 1991 through 2000 (includes corresponding  Graph/Chart) II-127  Table 32: World 10-Year Perspective for Human Vaccines by  Geographic Region - Percentage Breakdown of Dollar Sales for  US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),  Latin America and Rest of World Markets for Years 2003, 2008 &  2012 (includes corresponding Graph/Chart) II-128  Table 33: World Recent Past, Current & Future Analysis for  Prophylactic Vaccines by Geographic Region - US, Canada,  Japan, Europe, Asia-Pacific (excluding Japan), Latin America  and Rest of World Markets Independently Analyzed with Annual  Sales Figures in US$ Million for Years 2001 through 2010  (includes corresponding Graph/Chart) II-129  Table 34: World Long-term Projections for Prophylactic  Vaccines by Geographic Region - US, Canada, Japan, Europe,  Asia-Pacific (excluding Japan), Latin America and Rest of  World Markets Independently Analyzed with Annual Sales Figures  in US$ Million for Years 2011 through 2015 (includes  corresponding Graph/Chart) II-130  Table 35: World 10-Year Perspective for Prophylactic Vaccines  by Geographic Region - Percentage Breakdown of Dollar Sales  for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),  Latin America and Rest of World Markets for Years 2003, 2008 &  2012 (includes corresponding Graph/Chart) II-131  Table 36: World Recent Past, Current & Future Analysis for  Prophylactic Vaccines by Product Segment - Pediatric  Prophylactic Vaccines and Adult Prophylactic Vaccines Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2001 through 2010 (includes corresponding  Graph/Chart) II-132  Table 37: World Long-term Projections for Prophylactic  Vaccines by Product Segment - Pediatric Prophylactic Vaccines  and Adult Prophylactic Vaccines Markets Independently Analyzed  with Annual Sales Figures in US$ Million for Years 2011  through 2015 (includes corresponding Graph/Chart) II-133  Table 38: World 10-Year Perspective for Prophylactic Vaccines  by Product Segment - Percentage Breakdown of Dollar Sales for  Pediatric Prophylactic Vaccines and Adult Prophylactic  Vaccines Markets for Years 2003, 2008 & 2012 II-133  Table 39: World Recent Past, Current & Future Analysis for  Pediatric Prophylactic Vaccines by Geographic Region - US,  Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin  America and Rest of World Markets Independently Analyzed with  Annual Sales Figures in US$ Million for Years 2001 through  2010 (includes corresponding Graph/Chart) II-134  Table 40: World Long-term Projections for Pediatric  Prophylactic Vaccines by Geographic Region - US, Canada,  Japan, Europe, Asia-Pacific (excluding Japan), Latin America  and Rest of World Markets Independently Analyzed with Annual  Sales Figures in US$ Million for Years 2011 through 2015  (includes corresponding Graph/Chart) II-135 Table 41: World 10-Year Perspective for Pediatric Prophylactic  Vaccines by Geographic Region - Percentage Breakdown of Dollar  Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding  Japan), Latin America and Rest of World Markets for Years  2003, 2008 & 2012 (includes corresponding Graph/Chart) II-136  Table 42: World Recent Past, Current & Future Analysis for  Adult Prophylactic Vaccines by Geographic Region - US, Canada,  Japan, Europe, Asia-Pacific (excluding Japan), Latin America  and Rest of World Markets Independently Analyzed with Annual  Sales Figures in US$ Million for Years 2001 through 2010  (includes corresponding Graph/Chart) II-137  Table 43: World Long-term Projections for Adult Prophylactic  Vaccines by Geographic Region - US, Canada, Japan, Europe,  Asia-Pacific (excluding Japan), Latin America and Rest of  World Markets Independently Analyzed with Annual Sales Figures  in US$ Million for Years 2011 through 2015 (includes  corresponding Graph/Chart) II-138  Table 44: World 10-Year Perspective for Adult Prophylactic  Vaccines by Geographic Region - Percentage Breakdown of Dollar  Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding  Japan), Latin America and Rest of World Markets for Years  2003, 2008 & 2012 (includes corresponding Graph/Chart) II-139  Table 45: World, Recent Past, Current & Future Analysis for  Therapeutic Vaccines by Geographic Region - US, Canada, Japan,  Europe, Asia-Pacific (excluding Japan), Latin America and Rest  of World Markets Independently Analyzed with Annual Sales  Figures in US$ Million for Years 2001 through 2010 (includes  corresponding Graph/Chart) II-140  Table 46: World Long-term Projections for Therapeutic Vaccines  by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific  (excluding Japan), Latin America and Rest of World Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2011 through 2015 (includes corresponding  Graph/Chart) II-141  Table 47: World 10-Year Perspective for Therapeutic Vaccines  by Geographic Region - Percentage Breakdown of Dollar Sales  for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),  Latin America and Rest of World Markets for Years 2003, 2008 &  2012 (includes corresponding Graph/Chart) II-142  III. MARKET  1. The United States III-1  A.Market Analysis III-1  Outlook III-1  Current & Future Analysis III-1  Market Constraints III-1  Supply Shortages III-2  Pediatric Vaccines Market III-2  Market Focus Shifting From Pediatric Vaccines III-2  Growth Boosting Factors for US Pediatric Vaccines Market III-2  Demand Restraining factors for US Pediatric Vaccines Market III-3  Table 48: Pediatric Vaccine Market in the US: Annual  Sales for 2000-2005 (In Millions of Doses) (includes  corresponding Graph/Chart) III-3  Table 49: US Pediatric Vaccine Market: Percent of Doses  by Vaccine Type - 2000 through 2005 (includes  corresponding Graph/Chart) III-4  'Bright' Outlook for Therapeutic Vaccines III-4  Select Cancer Vaccines in Pipeline in the US III-4  Market Share of Key Players in North America III-5  Table 50: Leading Players in the North American Human  Vaccines Market (2005): Percentage Breakdown by Value  Sales for Merck, Sanofi-Aventis, Wyeth, GlaxoSmithKline,  and Others (includes corresponding Graph/Chart) III-5  The US Influenza Vaccine Market III-5  Table 51: The US Seasonal Influenza Vaccine Market -  Production and Distribution of Influenza Vaccine in Million  Units (includes corresponding Graph/Chart) III-5  Table 52: Funds Forwarded by HHS for Influenza Vaccine  Production (2005-2006) to Key Vaccine Manufacturers (In US  Dollars) (includes corresponding Graph/Chart) III-6  Influenza Vaccine Producers for the 2006-2007 Influenza Season III-6  Problems Effecting Timely Supply of Influenza Vaccine III-6  Table 53: Influenza Vaccines Market in the US (2005):  Percentage Breakdown of Value Sales for Sanofi Aventis,  Chiron, GSK, and Medimmune (includes corresponding  Graph/Chart) III-7  Key Statistics III-7  Table 54: Number of Children Under 5 Years of Age in the US  (In Millions) (includes corresponding Graph/Chart) III-7  Vaccines and Intended User Group III-8  Need for Immunization Schedule for Adults III-8  Federal Research and Grants III-9  National Cancer Institute III-9  National Institutes of Health (NIH) III-9  NIH Scientists Showcase Potential West Nile Virus Vaccine III-9  NIH Doles Out Grants to Biotech Companies III-9  Development Funds for HIV Vaccines III-10  Development Funds for Biodefense-Related Vaccines III-10  The National Institute of Allergy and Infectious Diseases  (NIAID) III-10  Intramural Research III-10  Extramural Divisions III-10  Vaccine Pricing in the US III-11  Table 55: The US Vaccine Market: Vaccine Prices in US$ Per  Dose (2002-2005) (includes corresponding Graph/Chart) III-11  Regulatory Environment III-11  Review Process Make Vaccines Safer III-11  Imports-Exports Scenario in the Recent Past III-12  Exports of Human Vaccines for 2004 III-12  Table 56: US Domestic Exports of Vaccines for Human  Medicine for the Year 2004 (Value in '000 US Dollars)  (includes corresponding Graph/Chart) III-12  Imports of Human Vaccines for 2004 III-12  Table 57: US Imports of Vaccines for Human Medicine for  the Year 2004 (Value in '000 US Dollars) (includes  corresponding Graph/Chart) III-12  Clinical Trials III-13  Product Developments III-20  Strategic Corporate Developments III-21  Select Players III-39  Alphavax Inc. III-39  Antigenics Inc. III-39  Avax Technologies, Inc. III-39  Avant Immunotherapeutics, Inc. III-40  Baxter International Inc. III-41  Cell Genesys Inc. III-41  Dendreon Corporation III-42  DOR Biopharma Inc. III-42  Dynavax Technologies Corp. III-43  Emergent BioSolutions Inc. III-43  GenPhar, Inc. III-44  IDM Pharma, Inc III-44  ImClone Systems, Inc. III-45  Ligocyte Pharmaceuticals, Inc III-45  Maxygen, Inc. III-45  MedImmune, Inc III-46  Merck & Company, Inc III-46  Micromet, Inc. III-47  Novartis Vaccines & Diagnostics, Inc. III-47  Novavax, Inc. III-47  Orchestra Therapeutics, Inc. III-48  Progenics Pharmaceuticals Inc. . III-48  Sanofi Pasteur Inc. III-49  Vaxin, Inc. III-49  Wyeth III-50  B.Market Analytics III-51  Table 58: US Recent Past, Current & Future Analysis for  Human Vaccines by Product Group/Segment - Prophylactic  Vaccines (Pediatric Prophylactic Vaccines and Adult  Prophylactic Vaccines) and Therapeutic Vaccines Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2001 through 2010 (includes corresponding  Graph/Chart) III-51  Table 59: US Long-term Projections for Human Vaccines by  Product Group/Segment - Prophylactic Vaccines (Pediatric  Prophylactic Vaccines and Adult Prophylactic Vaccines) and  Therapeutic Vaccines Markets Independently Analyzed with  Annual Sales Figures in US$ Million for Years 2011 through  2015 (includes corresponding Graph/Chart) III-51  Table 60: US Historic Review for Human Vaccines - Annual  Sales Figures in US$ Million for Years 1991 through 2000  (includes corresponding Graph/Chart) III-52  Table 61: US 10-Year Perspective for Human Vaccines by  Product Group/Segment - Percentage Breakdown of Dollar Sales  for Prophylactic Vaccines (Pediatric Prophylactic Vaccines  and Adult Prophylactic Vaccines) and Therapeutic Vaccines  Markets for 2003, 2008 & 2012 (includes corresponding  Graph/Chart) III-52  2. Canada III-53  A.Market Analysis III-53  Clinical Trial III-53  Strategic Corporate Developments III-53  B.Market Analytics III-55  Table 62: Canadian Recent Past, Current & Future Analysis  for Human Vaccines by Product Group / Segment - Prophylactic  Vaccines (Pediatric Prophylactic Vaccines and Adult  Prophylactic Vaccines) and Therapeutic Vaccines Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2001 through 2010 (includes corresponding  Graph/Chart) III-55  Table 63: Canadian Long-term Projections for Human Vaccines  by Product Group/Segment - Prophylactic Vaccines (Pediatric  Prophylactic Vaccines and Adult Prophylactic Vaccines) and  Therapeutic Vaccines Markets Independently Analyzed with  Annual Sales Figures in US$ Million for Years 2011 through  2015 (includes corresponding Graph/Chart) III-56  Table 64: Canadian Historic Review for Human Vaccines -  Annual Sales Figures in US$$ Million for Years 1991 through  2000 (includes corresponding Graph/Chart) III-56  Table 65: Canadian 10-Year Perspective for Human Vaccines by  Product Group/Segment - Percentage Breakdown of Dollar Sales  for Prophylactic Vaccines (Pediatric Prophylactic Vaccines  and Adult Prophylactic Vaccines) and Therapeutic Vaccines  Markets for 2003, 2008 & 2012 (includes corresponding  Graph/Chart) III-57  3. Japan III-58  A.Market Analysis III-58  Strategic Corporate Development III-58  B.Market Analytics III-59  Table 66: Japanese Recent Past, Current & Future Analysis  for Human Vaccines by Product Group/ Segment - Prophylactic  Vaccines (Pediatric Prophylactic Vaccines and Adult  Prophylactic Vaccines) and Therapeutic Vaccines Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2001 through 2010 (includes corresponding  Graph/Chart) III-59  Table 67: Japanese Long-term Projections for Human Vaccines  by Product Group/Segment - Prophylactic Vaccines (Pediatric  Prophylactic Vaccines and Adult Prophylactic Vaccines) and  Therapeutic Vaccines Markets Independently Analyzed with  Annual Sales Figures in US$ Million for Years 2011 through  2015 (includes corresponding Graph/Chart) III-60  Table 68: Japanese Historic Review for Human Vaccines -  Annual Sales Figures in US$$ Million for Years 1991 through  2000 (includes corresponding Graph/Chart) III-60  Table 69: Japanese 10-Year Perspective for Human Vaccines by  Product Group/Segment - Percentage Breakdown of Dollar Sales  for Prophylactic Vaccines (Pediatric Prophylactic Vaccines  and Adult Prophylactic Vaccines) and Therapeutic VaccinesMarkets for 2003, 2008 & 2012 (includes corresponding  Graph/Chart) III-61  4. Europe III-62  A.Market Analysis III-62  Vaccine Pricing in Europe III-62  Major Drawbacks III-62  Current & Future Analysis III-62  Regulatory Mechanism for Vaccines in Europe III-62  Select Players III-63  Table 70: Leading Players in the European Human Vaccines  Market (2005): Percentage Breakdown by Value Sales for  GlaxoSmithKline & Sanofi Pasteur, Wyeth, and Others  (includes corresponding Graph/Chart) III-63  Table 71: Influenza Vaccines Market in Europe (2005 &  2006): Percentage Breakdown of Value Sales for Sanofi  Pasteur, GSK, Novartis Vaccines, and Others in US$ Million  (includes corresponding Graph/Chart) III-63  Strategic Corporate Developments III-63  B.Market Analytics III-65  Table 72: European Recent Past, Current & Future Analysis  for Human Vaccines by Geographic Region - France, Germany,  Italy, UK, Spain, Russia, and Rest of Europe Markets  Independently Analyzed with Annual Sales Figures in US$  Million for Years 2001 through 2010 (includes corresponding  Graph/Chart) III-65  Table 73: European Long-term Projections for Human Vaccines  by Geographic Region - France, Germany, Italy, UK, Spain,  Russia, and Rest of Europe Markets Independently Analyzed  with Annual Sales Figu 

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