June 16, 2005
New Gene Chip May Be Early Cancer Diagnosis Tool
A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute's Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer. Additional results suggest that a relatively simple diagnostic test using a DNA microarray "chip" could enable early detection of some solid tumors, including lung cancer.
Mitochondrial DNA (mtDNA) plays a role in respiration and the cell's energy conversion mechanism. Since the late 1990s, researchers at the Johns Hopkins University School of Medicine have observed changes in mtDNA sequences in solid cancers, although the nature of the relationship remains uncertain. Their work suggested that particular changes in mtDNA might serve as early indicators for several types of solid cancer. Although promising, this approach is critically dependent on developing reliable, cost-effective, and highly sensitive methods of analysis to detect the cancer indicators against the background of natural variation in mtDNA.
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