October 20, 2008

Trius Antibiotics to Be Highlighted in 18 Presentations at ICAAC/IDSA

SAN DIEGO, Oct. 20 /PRNewswire/ -- Trius Therapeutics, Inc., a biopharmaceutical company developing "Best-in-Class" drugs for the treatment of serious bacterial infections, announced today that the results of multiple studies on its lead program, TR-701, and its other pipeline programs will be presented in eighteen presentations at the upcoming joint Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and Infectious Diseases Society of America (IDSA) meeting in Washington, DC. Thirteen of the presentations focus on TR-701, a second generation oxazolidinone that recently commenced Phase 2 clinical studies.

"Acceptance of these presentations by the ICAAC committee highlights the interest in and value of the TR-701 program, the Trius pipeline, and our underlying technologies," stated Jeffrey Stein, Ph.D., President and CEO of Trius Therapeutics. "We are especially pleased to provide details of our TR-701 Phase 1 clinical trial results that support the once-daily dosing and short course of therapy in our recently initiated Phase 2 study in complicated skin and skin structure infections (cSSSIs). It is also exciting to see that the results of studies by external investigators demonstrate the drug's increased potency and expanded spectrum of activity."

   The presentations are as follows:    Saturday, October 25th    (Poster Summary Session, Ballroom A/B, 10:00 am - 12:00 pm)    --  Oral Presentation: Overview of TR-701 and TR-700 Posters and       Presentations     (Poster Session 23, 12:15 pm - 1:15 pm)    --  F1-334: Discovery and SAR of a Novel Series of Pyrimidine       Antibacterials Targeting Methionyl-tRNA Synthase (MetRS)   --  F1-335: In Vitro Activity of Rx100472 Against Clinically Important       Bacteria   --  F1-336: Advanced Microbiology Study of Rx100472, A Novel       Methionyl-tRNA Synthetase (MetRS) inhibitor   --  F1-337: In Vivo Efficacy of Rx100472, A Novel Methionyl-tRNA       Synthetase (MetRS) Inhibitor     Sunday, October 26th    (Poster Session 92, 11:15 am - 12:15 pm)    --  A-985: Pharmacodynamics of TR-701 in a Mouse Thigh Infection Model       Against S. aureus ATCC 33591, a Methicillin-Resistant Isolate     Monday, October 27th    (Poster Session 196, 11:15 am - 12:15 pm)    --  F1-2060: MICs of TR-700, the Active Moiety of the Novel Oxazolidinone       Prodrug TR-701, for Linezolid-Susceptible and - Resistant Enterococci       and Staphylcocci   --  F1-2061: TR-700, a Novel Oxazolidinone, Tested Against       Linezolid-Resistant Gram-Positive Species with Well-Characterized       Resistance Mechanisms   --  F1-2062: In Vitro Pharmacodynamics of TR-700, the Active Moiety of       Prodrug TR-701, a Novel Oxazolidinone, in a Kill-Curve Model   --  F1-2063: Human Pharmacokinetics of TR-700 after Ascending Single Oral       Doses of the Prodrug TR-701, a Novel Oxazolidinone Antibiotic   --  F1-2064: Human Pharmacokinetics of TR-700 after Multiple Oral Doses of       200 and 400 mg of TR-701, a Novel Oxazolidinone Antibiotic   --  F1-2065: In Vitro and In Vivo Efficacy of TR-701 and TR-700 Versus the       Linezolid- and Methicillin-Resistant Staphylococcus aureus cfr Strain       CM/05   --  F1-2066: Demonstration of TR-701 Efficacy in a Mouse Inhalation       Anthrax Model   --  F1-2067: Absence of a Pressor Response to Oral Tyramine in Conscious       Telemeterized Rats Treated with the Novel Oxazolidinone TR-701:       Comparison to Linezolid   --  F1-2068: Quality Control Parameters for TR-700 Broth Microdilution       Susceptibility Tests   --  F1-2069: Relative Potency of TR-700, the Active Moiety of Prodrug       TR-701, Against Selected Bacterial Pathogens and Provisional Disk Test       Criteria   --  F1-2069a ("Late Breaker"): Hematological Effects of TR-701, Linezolid       and Placebo Administered for 21 Days in Healthy Subjects     (Poster Session 197, 11:15 am - 12:15 pm)    --  F2-2070: Structure Guided Design of Pyrimidine Antibacterials       Targeting Methionyl-tRNA Synthase (MetRS)    
Copies of these posters will be available on the Trius website following the ICAAC/IDSA meeting.

About Trius Therapeutics

Trius Therapeutics is discovering and developing innovative antibacterial drugs for the treatment of infections caused by drug-resistant pathogens. The company's lead drug candidate, TR-701, is a second generation oral and IV oxazolidinone antibiotic with potent activity against drug-resistant gram-positive bacterial pathogens including those resistant to Zyvox(R). Trius has licensed worldwide rights outside of Korea to TR-701 from Dong-A Pharmaceuticals. Trius' pipeline includes two preclinical programs being developed to treat serious infections including those caused by gram-negative bacterial pathogens. For more information, visit http://www.triusrx.com/.

Trius Therapeutics, Inc.

CONTACT: Cathy Yarbrough of Trius Therapeutics, Inc., +1-858-243-1814,[email protected]

Web Site: http://www.triusrx.com/