October 21, 2008
New Combination Promotes Collagen Production
Looking for youthful skin? Researchers announced on Monday that a process of using a topical solution made by the company DUSA Pharmaceuticals Inc and laser treatment encourages collagen production and helps revitalize skin that was damaged by the sun.
Their study established the importance of the procedure, currently being performed by doctors, that recovers the look of skin with wrinkles, fine lines and "sun spots", and explains how the procedure works.University of Michigan researchers experimented with photodynamic therapy that unites DUSA's Levulan, a product applied to the skin to amplify its sensitivity to light, and the pulsed dye laser treatment that uses short flashes of a single wavelength of light.
Researchers discovered that the therapy improved the production of collagen, a protein that gives skin its texture and elasticity, and encouraged the thickening of the top layer of the skin.
"We do believe that the treatment would, in fact, improve the appearance of patients' skin," said Dr. Jeffrey Orringer, the director of the University of Michigan's Cosmetic Dermatology and Laser Center.
"It lends molecular or scientific credibility to a procedure that's being done out there, and it's also the first step in understanding how to make this treatment more effective," he added.
The researchers executed the formula on the sun-damaged forearm skin of 25 volunteers and obtained tissue samples to see and record the transformations.
People tend to be excited about the improvement of the appearance of damaged skin, caused by years of sunbathing and exposure to the sun.
Photodynamic therapy currently being performed costs hundred of dollars, Orringer added.
The U.S. Food and Drug Administration accepted Levulan in 1999 to take care of precancerous skin lesions of the face or scalp known as actinic keratoses.
The results of the research indicated that collagen production is twice as successful with Levulan plus laser treatment as opposed to laser treatment by itself, Orringer said.
The complete research evaluation and findings are in the journal Archives of Dermatology.
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