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Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting

November 3, 2008

CALGARY, Nov. 3 /PRNewswire-FirstCall/ — Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY) announced today that it has achieved positive interim results in its U.K. combination REOLYSIN(R) and docetaxel clinical trial for patients with advanced cancers.

Prof. Hardev Pandha of the Royal Surrey Hospital, U.K., presented the results at the International Society for Biological Therapy of Cancer (iSBTC) annual meeting on November 1, 2008. The meeting was held in San Diego, California from October 31 – November 2, 2008.

Fourteen patients have been treated to date in the dose escalation portion of the trial and eleven patients are evaluable for response. The detailed results are summarized in the following table:

   -------------------------------------------------------------------------                          REOLYSIN Dose   Primary Tumour               TCID(50)     Cycles    Best Response   -------------------------------------------------------------------------   Breast                       1x10(10)        8      PR                                                       CR in liver   -------------------------------------------------------------------------   Gastric                      3x10(10)        8*   PR                                                       32% reduction in                                                        lymph nodes   -------------------------------------------------------------------------   Mesothelioma                 1x10(10)        6      Minor response                                                       23% reduction in                                                        lymph nodes   -------------------------------------------------------------------------   Prostate                      3x10(9)        6      SD on scans                                                       30% reduction in PSA   -------------------------------------------------------------------------   Squamous Cell                 3x10(9)        3      Minor response   Carcinoma                                           26% reduction in   Head and Neck                                        lymph node   -------------------------------------------------------------------------   Unknown                       3x10(9)        6      SD   -------------------------------------------------------------------------   Pancreas                     3x10(10)        6*   SD   -------------------------------------------------------------------------   Prostate                     3x10(10)        5*   SD   -------------------------------------------------------------------------   Prostate                     3x10(10)        5      SD   -------------------------------------------------------------------------   Melanoma                     1x10(10)        4      SD   -------------------------------------------------------------------------   Pancreas                     3x10(10)        2      SD, but progressed                                                        clinically   -------------------------------------------------------------------------    * patients still on study. CR=complete response,       PR=partial response, SD=stable disease   

“These are extraordinary results for a Phase I trial,” said Dr. Brad Thompson, President and CEO of Oncolytics. “To see tumour stabilization or better in this patient population is highly unusual.”

The trial (REO 010) has two components. The first is an open-label, dose-escalating, non-randomized study of REOLYSIN(R) given intravenously with docetaxel every three weeks. In this portion of the trial, which was completed in August 2008, standard dosages of docetaxel were delivered to patients with escalating dosages of REOLYSIN(R) intravenously. The second component of the trial includes the enrolment of a further nine patients at the top dose of REOLYSIN(R) in combination with a standard dosage of docetaxel. Patients may receive up to eight cycles of treatment in this study.

Eligible patients include those who have been diagnosed with advanced or metastatic solid tumours including bladder, lung, prostate or upper gastro-intestinal cancers that are refractory (have not responded) to standard therapy or for which no curative standard therapy exists. The primary objective of the trial is to determine the Maximum Tolerated Dose (MTD), Dose-Limiting Toxicity (DLT), recommended dose and dosing schedule and safety profile of REOLYSIN(R) when administered in combination with docetaxel. Secondary objectives include the evaluation of immune response to the drug combination, the body’s response to the drug combination compared to chemotherapy alone and any evidence of anti-tumour activity.

The poster will be available today on the Oncolytics website at http://www.oncolyticsbiotech.com/.

About Oncolytics Biotech Inc.

Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as potential cancer therapeutics. Oncolytics’ clinical program includes a variety of Phase I/II and Phase II human trials using REOLYSIN(R), its proprietary formulation of the human reovirus, alone and in combination with radiation or chemotherapy. For further information about Oncolytics, please visit http://www.oncolyticsbiotech.com/.

This press release contains forward-looking statements, within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements, including the implication of the materials presented at this meeting with respect to REOLYSIN(R), the Company’s expectations related to the results of trials investigating delivery of REOLYSIN(R), the Company’s analysis of the results of the Phase I trial, and the Company’s belief as to the potential of REOLYSIN(R) as a cancer therapeutic, involve known and unknown risks and uncertainties, which could cause the Company’s actual results to differ materially from those in the forward-looking statements. Such risks and uncertainties include, among others, the availability of funds and resources to pursue research and development projects, the efficacy of REOLYSIN(R) as a cancer treatment, the success and timely completion of clinical studies and trials, the Company’s ability to successfully commercialize REOLYSIN(R), uncertainties related to the research and development of pharmaceuticals, uncertainties related to the regulatory process and general changes to the economic environment. Investors should consult the Company’s quarterly and annual filings with the Canadian and U.S. securities commissions for additional information on risks and uncertainties relating to the forward-looking statements. Investors are cautioned against placing undue reliance on forward-looking statements. The Company does not undertake to update these forward-looking statements, except as required by applicable laws.

Oncolytics Biotech Inc.

CONTACT: Oncolytics Biotech Inc., Cathy Ward, 210, 1167 Kensington CrNW, Calgary, Alberta, T2N 1X7, Tel: (403) 670-7377, Fax: (403) 283-0858,cathy.ward@oncolytics.ca; The Equicom Group, Nick Hurst, 325, 300 5th Ave. SW,Calgary, Alberta, T2P 3C4, Tel: (403) 538-4845, Fax: (403) 237-6916,nhurst@equicomgroup.com; The Investor Relations Group, Erika Moran, 11 StoneSt, 3rd Floor, New York, NY, 10004, Tel: (212) 825-3210, Fax: (212) 825-3229,emoran@investorrelationsgroup.com




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