Next Safety Develops an Air-Based Asthma Medication Inhaler That Does Not Use a Refrigerant Propellant
albuterol, a fast-acting bronchial dilator, currently use propellants such as
ozone-depleting CFC’s, which are banned by the FDA beginning
refrigerants and eject the medicine, albuterol, at near-supersonic speeds.
The Next Safety device supplies medication in a stream of air by ejecting
the medication from a microfluidic pump automatically as the patient breathes,
solving three problems:
(1) Propellants are eliminated. Patients are no longer required to inhale
(2) The medicine is not ejected at high speeds, where it is deposited on
the back of the throat and ingested. This is such a concern that certain
manufacturers of the new HFA-based albuterol inhalers recommend that patients
“rinse and spit” after each treatment.
(3) Patients do not need to time their inhalation to match the push of a
button. This is particularly important when administering albuterol to
children where the parent is pressing a button hoping the child will breath at
the same time. Therefore, parents can never be certain of dosing, which is one
reason why 25% of all emergency room visits in the US are related to asthma.
The other method used to dose albuterol is the nebulizer, a large
compressor-driven device that essentially sprays droplets of albuterol while a
child breathes from a mist for a 20 – 30 minute period. This treatment,
invented in 1975, is cumbersome and often not available to an asthmatic when a
fast-acting dose of albuterol is needed.
technology, explains: “The device uses a silicon microfluidic pump to eject
droplets of an off-the-shelf FDA-approved solution of albuterol sulfate in
water that are a predetermined size into an air stream created by a miniature
blower to deliver the droplets at the same speed of the patient’s inhalation
and in the correct size range for bronchial delivery.”
According to Dr.
Safety, “The platform offers the ability to deliver not only albuterol in air,
but also other medications for treating asthma, such as fluticasone propionate
and salmeterol xinofoate, the components of Advair.” Certain chemical patents
for Advair expired in
The device also provides an electronic output to PDA’s so that, in the
future, doctors can monitor the results of specific doses of medications in
addition to patient compliance.
Advanced designs of the platform use measurements of exhaled nitric oxide
(NO) together with peak respiratory flow, which when combined are a predictor
of an asthma attack, to automatically adjust doses and provide alarms to
physicians and parents.
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SOURCE Next Safety, Inc.