Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone
science, resveratrol pill users are best advised to consume modest doses of
resveratrol plus an array of antioxidant molecules as typically provided in 3
to 5 glasses of aged, red wine, rather than resveratrol alone.
The most recent study shows mega-dose resveratrol alone fails to prolong
the life of laboratory mice. In fact, mega-doses shortened the life of
animals compared to a standard calorie diet with no resveratrol. [Cell
Metabolism. 2008 Aug; 8:157-68]
“While resveratrol (rez-vair-ah-trol), an antioxidant molecule
concentrated in red wine (about 1 milligram per glass), is touted for its
health properties, partially explaining the French Paradox (why French wine
drinkers have cardiac mortality rates 30% lower than North Americans despite
their high-calorie, high-fat diets), it is not the sole molecule responsible
for longevity,” says
brand of resveratrol dietary supplement.
“The total array of red wine molecules found in the best red wine, about
60 milligrams per 5-ounce glass, or 180-300 milligrams in 3 to 5 glasses, is
the suggested healthy dosage range,” says Sardi.
Consistently, studies show modest doses of red wine lower mortality rates
over abstention or over-consumption. [American Journal Epidemiology 1986 Sep;
124(3):481-9] Red wine pills offer the advantage of no alcohol, no calories
or sulfite preservatives.
Cause of shortened lifespan
The negative effect upon lifespan with mega-dose resveratrol may emanate
from over-inhibition of tumor necrosis factor (TNF), an inflammatory factor.
Excessive TNF leads to inflammation, while too little impairs the immune
system, says Sardi.
“We know that over-inhibition of TNF in humans increases the risk for
lymphoma (cancer that originates in lymphocytes, a type of white blood cell),”
says Sardi. [Therapeutics Clinical Risk Management 2007 Jun; 3(2):245-58]
“When laboratory mice were given mega-dose resveratrol they did not live as
long and largely succumbed to lymphoma. Resveratrol is a known TNF
inhibitor,” adds Sardi. [Biochemical and Biophysical Research Communications
Confusing dosage advice
While longevity seekers have been hearing a lot about resveratrol in the
past four years, since an
longevity gene known as Sirtuin 1, advice concerning dosage has been confusing
A 2006 mouse study suggested consumers would have to drink about 750 to
1500 bottles of red wine a day to live longer (24 milligrams per kilogram of
body weight), but the longevity effect was only demonstrated among mice
engorged with a fat-laden diet (60% fat calories vs. 35% for the typical human
diet), which isn’t a real-world example.
When the data on mice fed a standard calorie diet were analyzed and
published in 2008 [Cell Metabolism. 2008 Aug; 8(2):157-68], ultra-high dose
resveratrol (360 mg and 1565 mg, human equivalent dosage) actually stunted the
lifespan of mice. So the public has been misled concerning dosage since 2006
[Nature 2006 Nov 16; 444:337-42], and may have never heard about the 2008
report, says Sardi.
Lower dose resveratrol accompanied by an array of other small molecules
may be superior to resveratrol alone. According to a mouse study conducted by
Longevinex(R), published in the
Gerontology [2008 Sept; 43(9):859-66], far more longevity genes were activated
in heart tissue by Longevinex (9-fold more) than plain resveratrol, at a dose
that was 17-320 times lower than doses used in prior studies.
“A synergistic effect has been demonstrated with the array of antioxidant
molecules provided in Longevinex(R), compared to resveratrol alone,” says
Sardi. Other studies also corroborate that resveratrol works better when
accompanied by other molecules, at lower doses. [Journal Medicinal Food 2008
Dec; 11:773-83; Translational Oncology 2008 March; 1:19-27; Life Science 2008
Sardi says longevity seekers often demand human lifespan studies, not
realizing such a study would be impractical, taking 100 years to complete.
Mouse longevity studies take about 3-4 years and cost more than a million
dollars, so more economical gene array studies are performed and compared
against a calorie restricted diet, which is a known intervention that prolongs
life in all life forms. Longevinex(R) also sponsored an unpublished study
showing it activated far more genes in brain tissue than plain resveratrol.
Longevinex(R) is a patent-applied-for matrix providing 250 milligrams of
gene-controlling molecules (resveratrol, quercetin, rice bran IP6, ferulic
acid, vitamin D), and is currently the only resveratrol-based dietary
supplement to have been successfully studied in humans. Researchers at
anti-inflammatory action among endurance athletes compared to green tea
molecules or quercetin alone.
Longevinex(R) is microencapsulated for stability and long-term shelf life,
and is micronized to enhance absorption. Longevinex(R) contains no alcohol.
Longevity seekers are invited to visit the website at www.longevinex.com