Fructose linked to insulin resistance
Posted on: Wednesday, 4 March 2009, 11:21 CST
A U.S. study in mice sheds light on the insulin resistance that can come from diets loaded with high-fructose corn syrup, researchers said.
The study, published in the journal Cell Metabolism, showed that mice on a high-fructose diet were protected from insulin resistance when a gene known as transcriptional coactivator PPARg coactivator-1b -- PGC-1b -- was knocked down
in the animals' liver and fat tissue. PGC-1b coactivates a number of transcription factors that control the activity of other genes, including one responsible for building fat in the liver.
There has been a remarkable increase in consumption of high-fructose corn syrup,
Gerald Shulman of Yale University School of Medicine said in a statement. Fructose is much more readily metabolized to fat in the liver than glucose is and in the process can lead to nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease in turn leads to hepatic insulin resistance and type 2 diabetes, Shulman said.
Metabolic syndrome and type 2 diabetes have both reached epidemic proportions worldwide with the global adoption of the Westernized diet along with increased consumption of fructose, the researchers said.
The study has revealed the transcriptional coactivator PGC-1b as a missing link between fructose intake and metabolic disorders,
Carlos Hernandez and Jiandie Lin of the University of Michigan Medical Center, Ann Arbor, wrote in an accompanying commentary.
Source: United Press International
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Posted by Audrae Erickson on 03/06/2009, 03:55 High fructose corn syrup has the same number of calories as sugar and is handled similarly by the body. As noted by the American Medical Association in June 2008, “Because the composition of HFCS and sucrose are so similar, particularly on absorption by the body, it appears unlikely that HFCS contributes more to obesity or other conditions than sucrose.” There is no scientific evidence to suggest that high fructose corn syrup is responsible for diabetes. All caloric sweeteners trigger an insulin response in the body. In fact, table sugar, honey and high fructose corn syrup trigger about the same insulin release, because they contain nearly equal amounts of fructose and glucose. Many confuse pure “fructose” with “high fructose corn syrup,” a sweetener that never contains fructose alone, but always in combination with a roughly equivalent amount of a second sugar (glucose). Recent studies that have examined pure fructose - often at abnormally high levels - have been inappropriately applied to high fructose corn syrup and have caused significant consumer confusion. Audrae Erickson President Corn Refiners Association www.SweetSurprise.com |
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