Study Links Internal Source of Aging and Skin Damage
Nu Skin Presents Findings at Asian Societies of Cosmetic Scientists Meeting
“We know that arNOX, which is an internal source of aging, generates damaging superoxide free radicals at a rate that accelerates as we age,” said
“New understanding of skin biology and the internal contributors to skin damage and aging are leading to novel technologies for cosmeceutical products,” said
About the Study
The study measured arNOX activity and autofluorescence in punch biopsies of dermis and epidermis and compared that to the age of the sample subject. arNOX activity increased as the age of the subjects increased and correlated well with the autofluorescence of the skin. Autofluoresence is a way of measuring cross-linked molecules in collagen and elastin, two important components of the skin’s extracellular matrix that give structure and elasticity to the skin. When these proteins are damaged, they cross-link and become rigid, contributing to the appearance of lines and wrinkles and discoloration. Cross-links that occur between collagen and elastin can be created by a number of sources, including from superoxide free radicals. Previous studies (Kern, 2008(i); Morre 2003(ii)) show superoxide free radicals are generated by arNOX.
Authors of the study are
The arNOX enzyme is one in a class of newly-identified ECTO-NOX (external NADH oxidase or ENOX) proteins that are located on external cell membranes. ECTO-NOX proteins become increasingly active to generate additional metabolic energy as cell mitochondria age and produce less energy. arNOX has been identified in all fluids and cells tested, including serum and saliva, as well as the dermis and epidermis. Its unique property is that it generates superoxide at the cell surface that is capable of damaging adjacent cells, lipoproteins, and other structural components of the skin’s extracellular matrix, such as collagen and elastin.
The 9th Scientific Conference on the Asian Societies of Cosmetic Scientists on
For 25 years, Nu Skin Enterprises, Inc. has been demonstrating its tradition of innovation through its comprehensive anti-aging product portfolio, independent business opportunity and corporate social responsibility initiatives. Nu Skin’s scientific leadership in both skin care and nutrition has established Nu Skin as a premier anti-aging company, evidenced in its patent-pending ageLOC(TM) technology and flagship products including the Galvanic Spa(R) System II, Tru Face(R) Essence Ultra, LifePak(R) nano and the g3 nutrition beverage. A global direct selling company, Nu Skin operates in 48 markets throughout
(i) Kern, D., Draelos, Z.D., Morre, D.M., and Morre, D.J. Age-related NADH Oxidase (arNOX) Activity of Epidermal Punch Biopsies Correlate with Subject Age and arNOX Activities of Serum and Saliva. Supplement to the Journal of Investigative Dermatology, April 2008; 128(1), S57. (ii) Morre DM, Guo F, Morre DJ. An aging-related cell surface NADH oxidase (arNOX) generates superoxide and is inhibited by coenzyme Q. Mol Cell Biochem. 2003 Dec; 254(1-2):101-9.
SOURCE Nu Skin Enterprises, Inc.