Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)
Now researchers in
The results of the study are consistent with an earlier research study conducted among mice which showed that the combination of resveratrol, quercetin and rice bran phytate-IP6 (Longevinex(R)) exerted a 9-times greater genomic effect than plain resveratrol or a calorie restricted diet. [Experimental Gerontology 2008 Sep; 43(9):859-66]
Researchers instilled various white and resveratrol-rich red wines as well as research-grade resveratrol into lab dishes with various types of cells (brain, lung, colon, cervical, kidney). Surprisingly researchers found the total array of molecules in red wine, but not white wine, produced a far greater biological effect than resveratrol alone. Furthermore, the beneficial effects were produced independently from alcohol or activation of the Sirtuin1 gene, considered a survival and longevity gene.
Only at higher concentrations did resveratrol cause unhealthy cells to die off (21%), compared to untreated cells (6%). Such a high concentration may produce long-term side effects in humans. But within 24 hours, red wine abolished virtually all (100%) the unhealthy cells. Red wine exerted its effect by disarming protective antioxidant systems.
Researchers caution that this is only a lab dish study and that the results are theoretical. But they seem to mirror the health-giving properties attributed red wine as observed in human populations in
The researchers speculate that “instead of a single molecule (like resveratrol) present in wine, … the combination of molecules in red wine … contribute result in a combined effect with positive outcome.”
“The synergism that nature produces, as seen in wine, may never be reproduced in prescription drugs for this reason,” says Sardi. “The development of a plain resveratrol drug may not be as productive as first imagined,” he says.
The patent-pending Longevinex(R) formula provides an array of molecules including three found naturally in red wine – resveratrol, quercetin and ferulic acid. The dosage of these molecules in Longevinex(R) is equivalent to what is provided in 3-5 glasses of red wine (180-300 mg), considered the safe and effective range observed in wine-drinking populations. [British Medical Journal 1991
The study was published in an early online edition (
For more information about Longevinex(R), please visit www.longevinex.com
Reference: Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Experimental Cell Research 2009