Translating Stem Cell Technology into Treatment

Doctors and dentists who treat diseases of the mouth may one day benefit from laboratory studies underway now on human embryonic stem cells.

Researchers from Tufts University are using tissue engineering principles to transform these stem cells into the complex tissues found in the oral cavity. Using a two step process, they’ve already created such tissues in the lab, showing for the first time that it’s possible to produce the multiple cell types necessary to form complex, multilayer tissues from a single source of stem cells.

The potential for these tissues to impact human health are significant. Not only could they be used as a source for oral transplantations, the authors also believe they will answer many of the questions scientists have now about the overall stability and safety of human embryonic stem cells used in this manner.

The researchers predict stem cell therapies will be available in the future to treat a wide range of oral diseases, including those affecting the gums, cheeks, lips, and other parts of the mouth.

SOURCE: Presented at the 87th General Session of the International Association for Dental Research, April 4, 2009