Preclinical Data From Amgen’s Oncology Pipeline to be Presented at AACR
Early Research Suggests that Understanding the Fundamental Mechanism of Angiogenesis is More Complicated Than Understanding the Function of VEGF – A
Amgen Launches Angiogenesis Website
Data will be presented on investigational compounds AMG 386, a peptibody that binds to and inhibits angiopoietins 1 and 2; AMG 479, a fully human monoclonal antibody antagonist of the type 1 insulin-like growth factor receptor (IGF-1R) and AMG 102, a fully human monoclonal antibody antagonist of HGF, the ligand for the c-Met receptor.
“The data being presented at this meeting further our biologic understanding of these novel compounds and pathways, and inform our thinking regarding opportunities to develop predictive or prognostic biomarkers,” said
Selected Abstracts of Interest -- Assessment of angiogenesis inhibitors in the retinopathy of prematurity model in mice Overview: Examined the inhibition of the VEGF/VEGFR pathway with AMG 273 and the inhibition of the angiopoietin/Tie2 pathway with AMG 386 Lead author: Estrada J. Abstract No. 140 (Sunday, April 19, 2009, 8:00 am - 12:00 pm) -- Involvement of the CSF-1/CSF-1R interaction in the control of angiogenesis Overview: Two different neutralizing rat anti murine CSF-1R monoclonal antibodies (mAb), M279 and AFS98 were evaluated for their effect on mouse corneal angiogenesis and corneal macrophage recruitment in vivo Lead author: Liu H. Abstract No. 1106 (Sunday, April 19, 2009, 1:00 pm - 5:00 pm) -- Complementary and opposing effects of angiopoietin-1 and angiopoietin-2 inhibitors on tumor blood vessels and normalization Overview: Aimed to elucidate the effects of Angiopoietin (Ang) 1 and Ang2 on the tumor vasculature of a human colon carcinoma model (Colo205) using peptide-Fc fusion proteins (peptibodies) specifically targeting Ang1 (mL4-3) or Ang2 (L1-7(N)) alone or in combination Lead author: Falcon B. Abstract No. 1996 (Monday, April 20, 2009, 9:40 am - 9:55 am) -- AMG 479, a novel IGF-1R antibody, inhibits endometrial cancer cell proliferation through disruption of the P13K/Akt and MAPK pathways Overview: Evaluated the effect of a novel antibody to the IGF-1R (AMG 479) on cell proliferation and expression of key targets involved in IGF-1R signaling in endometrial cancer cells Lead author: Mendivil A. Abstract No. 2804 (Monday, April 20, 2009, 1:00 pm - 5:00 pm) -- AMG 479, a fully human anti-IGF-1R monoclonal antibody, inhibits rapamycin-induced Akt activation in sarcoma cell lines Overview: Evaluated whether AMG 479 could inhibit this feedback-loop mechanism and thus increase the efficacy of rapamycin and its analogs (mTOR inhibitors). Lead author: Beltran P. Abstract No. 2805 (Monday, April 20, 2009, 1:00 pm - 5:00 pm) -- Dual targeting of the receptor tyrosine kinase EGFRvIII and HGF:c-Met signaling in models of glioblastoma multiforme (GBM) Overview: Examined the effect of combining a fully human neutralizing antibody targeting the HGF:c-Met axis (AMG 102), with a fully human antibody binding to the EGFR and EGFRvIII (panitumumab) to overcome resistance to HGF:c-Met based therapeutic strategies in GBM Lead author: Johns T. Abstract No. 2044 (Monday, April 20, 2009, 1:10 pm - 1:25 pm) -- Antagonistic antibodies to c-fms block c-fms-mediated activities, reduce tumor-associated macrophages and decrease tumor growth in preclinical models Overview: Antagonistic antibodies to c-fms were evaluated for their effects on monocytic cell function in vitro and tumor-associated macrophages (TAMs) and tumor growth in vivo Lead author: Bonham L. Abstract No. 2077 (Monday, April 20, 2009, 3:40 pm - 3:55 pm) -- Erythropoietin Receptor (EpoR) Was Expressed at Low to Undetectable Levels in Tumor Cell Lines: Expression Was Not Regulated by Hypoxia and No Epo-Induced Downstream Signaling Was Detectable Overview: EpoR, mRNA and protein expression were surveyed in 67 tumor-derived cell lines from ovary, breast, head and neck, lung, brain, prostate, cervix, liver, colon and blood Lead author: Swift S. Abstract No. 4283 (Tuesday, April 21, 2009, 1:00 pm - 5:00 pm)
Amgen Launches Educational Interactive Angiogenesis Website
Amgen would like to invite healthcare professionals to visit http://angiogenesis.amgen.com, where the science of angiogenesis comes to life. Angiogenesis, a fundamental mechanism in normal development and cancer, involves multiple cellular regulators that include the angiopoietins, the VEGF family and other regulators. Amgen has developed an interactive website that will provide users with a cinematic experience through which to view the process of tumor vessel growth.
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