April 16, 2009

Traveler’s Diarrhea Vaccine May Be Available Soon

According to researchers, a test vaccine against Campylobacter jejuni, a major cause of traveler's diarrhea, provided protection against infection in mice and monkeys and may ultimately have human application.

Also, C. jejuni not only causes diarrhea, but is associated with a number of "important sequelae," including inflammatory bowel disease, Dr. Patricia Guerry, senior investigator, told Reuters Health.  There are no licensed vaccines for C. jejuni currently available.

Guerry of the Naval Medical Research Center, Silver Spring, Maryland and colleagues developed a vaccine for C. jejuni and tested it in mice and monkeys challenged with infection, according to the report in the March issue of Infection and Immunity.  Mice demonstrated significant immune response and reduction in disease, following vaccination.

The vaccine also protected monkeys from diarrhea caused by C. jejuni.

"We are very excited about these results," said Guerry. She thinks that a vaccine that could protect against various types of C. jejuni is "very feasible."

Guerry added that her team has recently obtained funding from National Institute of Allergy and Infectious Diseases to continue their studies.


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