Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells
Study Presented at 2009 AACR Meeting Highlights Potential Therapeutic Approach to Treat Patients Unresponsive to Erbitux and Vectibix
Micromet’s researchers converted cetuximab and panitumumab into novel bispecific antibodies based on Micromet’s proprietary BiTE technology. Both of Micromet’s EGFR BiTE antibodies were able to direct T cells against cetuximab/panitumumab-resistant human colorectal cancer cells harboring KRAS and BRAF mutations, resulting in the destruction of these cancer cells. In mice, daily EGFR BiTE antibody doses as low as 0.1 microgram/kilogram were sufficient to prevent tumor growth from mutated human colorectal cancer cells. Studies in a relevant non-human primate species suggest that active serum levels of the cetuximab-based BiTE antibody are tolerated.
“The data show that our BiTE technology can overcome significant limitations of conventional monoclonal antibodies,” commented
(1)Lutterbuese, R. et al. Highly efficient lysis of KRAS- and BRAF-mutated human colon cancer cells by T cell-engaging BiTE antibodies derived from anti-EGFR antibodies cetuximab and panitumumab AACR Annual Meeting 2009, abstract no. 3251
(2)Tol, J. et al., N. Engl. J. Med. 360 : 563-572 (2009)
(4)Amado, R.G. et al., J. Clin. Oncol. 26: 1626-1634 (2008)
(5)Bargou, R. et al., Science 321: 974-977 (2008)
Micromet, Inc. (www.micromet-inc.com) is a biopharmaceutical company with offices in
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SOURCE Micromet, Inc.