Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting
Sponsored by Tigris, the research was led by
Dr. Burger said the findings offer particular hope to those women battling triple-negative breast cancer. “We could now find a way to treat every kind of invasive, metastatic breast cancer, the ER-positive and ER-negative types with AFP-464,” said Dr. Burger. “The synergism between AFP-464 and vorinostat in the triple negative breast cancer cell lines is very impressive.”
AFP464 is nearing completion of Phase I clinical testing at Jules Bordet Institute in
“Patients with triple negative breast cancer do not benefit from endocrine therapy or molecularly targeted therapy such as trastuzumab because they lack the targets for these drugs,” said Dr.
AFP-464, a Lysol prodrug of aminoflavone (AF), undergoes rapid conversion to AF by nonspecific plasma esterases. It has shown a unique pattern of growth inhibitory activity in the NCI’s 60 tumor cell line screen, with breast, ovarian, lung and renal lines exhibiting particular sensitivity. The mechanism of action of AF is believed to be that treatment with AF results in translocation of the arylhydrocarbon receptor (AhR; a transcriptional regulator of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with the xenobiotic-response element (XRE) sequence on the CYP1A1 promoter region, causing induction of CYP1A1 transcription. This enzyme expression converts AF to metabolites that are covalently bound to DNA. This results in phosphorylation of p53 with induction of the p53 downstream target p21Waf1/Cip1 and apotosis.
About Tigris Pharmaceuticals, Inc.
Tigris Pharmaceuticals, Inc. is a privately held biopharmaceutical company that develops therapeutic technologies, using a translational research approach, for use in oncology and other areas of unmet medical need. Tigris’ mission is to efficiently move its existing and future technologies through the various stages of clinical development in order to meet patients’ needs for safe and effective treatments of human illnesses.
About the Barbara Ann Karmanos Cancer Institute
Located in mid-town
This news release contains forward-looking statements that involve risks and uncertainties that could cause our actual results and experiences to differ materially from anticipated results and expectations expressed in such forward-looking statement. These forward-looking statements include, without limitation, statements regarding the mechanism of action of AFP-464, its potential advantages, its potential for use in treating cancer, as well as the timing, progress and anticipated results of the clinical development and regulatory processes concerning AFP-464. These statements are based on our current beliefs and expectations as to such future outcomes, and are subject to known and unknown risks and uncertainties that may cause actual future experience and results to differ materially from the statements made. Factors that might cause such a material difference include, among others, risks that the results of clinical trials will not support our claims or beliefs concerning the effectiveness of AFP-464, our ability to finance our development of AFP-464, regulatory risks, and our reliance on third party researchers and other collaborators. We assume no obligation to update these statements, except as required by law.
SOURCE Tigris Pharmaceuticals, Inc.