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Rib-X Pharmaceuticals Announces Presentations at the 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

May 7, 2009

NEW HAVEN, Conn., May 7 /PRNewswire/ — Rib-X Pharmaceuticals, Inc. (“Rib-X” or the “Company”), a development-stage company focused on the discovery and development of novel antibiotics for the treatment of antibiotic-resistant infections, today announced that researchers will be presenting two presentations and two posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) taking place in Helsinki, Finland from May 16-19, 2009.

Independent researchers, Dr. Franciose van Bambeke and Dr. Sandrine Lemaire, both from Universite Catholique de Louvain, will each make oral presentations describing the unique microbiological and pharmacodynamic properties of Rib-X’s novel oxazolidinone, radezolid, during a session entitled Pharmacokinetics/Pharmacodynamics: Clinical Relevance, on Saturday, May 16th.

Additionally, Rib-X researchers will be presenting two posters on delafloxacin, one of which discusses the activity and efficacy of delafloxacin in a Phase 2 clinical trial for complicated Skin and Skin Structure Infections. The second poster session details the in vitro activity of delafloxacin against a large, worldwide panel of methicillin-resistant Staphylococcus aureus.

    Details on the presentations and abstracts are as follows:

     Date        Time    Session          Title                Location/Poster

    May 16,    3:06pm -   PK/PD:     The novel oxazolidinone   Lecture Hall 3a
     2009      3:18pm     Clinical   radezolid (RX-1741)
                          Relevance  accumulates in THP-1
                                     macrophages: comparative
                                     studies with linezolid
                                     and azithromycin.

    May 16,    3:18pm -   PK/PD:     Radezolid (RX-1741), a    Lecture Hall 3a
     2009      3:30pm     Clinical   novel oxazolidinone, is
                          Relevance  active against
                                     intracellular S. aureus,
                                     L. monocytogenes and L.
                                     pneumophila phagocytosed
                                     by human THP-1 macrophages.

    May 17,    1:30pm -   Poster     In vitro activity of      Topic 31: New
     2009      2:30pm     Session 3  delafloxacin against      antimicrobials
                                     methicillin-resistant     against Gram-
                                     Staphylococcus aureus     positives
                                     from the United States,   Poster #1080
                                     Europe and Asia.

    May 18,    1:30pm -   Poster     Results of a Phase 2      Topic 71:
     2009      2:30pm     Session 5  Study Comparing Two       Clinical trials
                                     Doses of Delafloxacin to  of antibiotics
                                     Tigecycline in Adults     Poster #1794
                                     with Complicated Skin and
                                     Skin Structure Infections

About Rib-X Pharmaceuticals, Inc.

Rib-X Pharmaceuticals, Inc. is a product-driven small molecule drug discovery and development company focused on the structure-based design of new classes of antibiotics. NDAs for Rib-X’s most advanced compounds, delafloxacin and radezolid, are anticipated in the 2011/2012 timeframe. The Company’s underlying drug discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in protein synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ribosome. The Company’s integrated research strategy, which combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, allows it to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X’s iterative intelligent engine has yielded several distinctive new antibiotics that can be used for the treatment of either community- or hospital-acquired infections. The Company has recently completed Phase 2 trials in cSSTI with the IV form of delafloxacin, and is currently in Phase 2 trials with radezolid (RX-1741), an oxazolidinone that was discovered at Rib-X, as an oral/IV agent for treatment of serious Gram-positive infections and community or hospital acquired pneumonias. The RX-04 discovery program is developing novel classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the RX-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus, multidrug-resistant Streptococcus pneumoniae and S. pyogenes.

For more information on the Rib-X mission and the pipeline, please visit the Company website at www.rib-x.com.

SOURCE Rib-X Pharmaceuticals, Inc.


Source: newswire



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