Viral Genetics Has Option Under Issued Key Patent for Cancer Drug
“This patent represents the first method for treating drug resistant cancer using metabolic disruption, an approach targeting the distinct cancer-specific metabolic activities that can distinguish cancer cells in general, and many drug resistant cancer types, in specific, from normal cells in normal tissues,” said
“We are very excited that the Patent Office has recognized the significance of work we first pioneered over eight years ago. The scientific community is now coming to accept the approach, metabolic disruption, as an extremely promising method for helping cancer patients.”
The new therapies use metabolic disruption as a treatment of cancers, including multi-drug resistant cancers. This process is accomplished by the administration of 2-deoxy-D-glucose to inhibit high rate glucose metabolism, characteristic of cancer cells. The administration of 2-deoxy-D-glucose can be used in combination with current, standard chemotherapeutics and/or in combination with etomoxir, an inhibitor of fatty acid oxidation. Drug resistant tumor cells commonly use fatty acid metabolism to meet their distinct energy requirements. Disrupting these metabolic pathways can cause apoptosis of the cancer cells without significant adverse effect on non-cancer cells.
Viral Genetics’ approach addresses one of the primary reasons chemotherapy and radiation are not always effective – the development of drug resistance. Although the standard therapies may initially destroy significant numbers of tumor cells, a small number of resistant tumor cells may be left behind. Those resistant cells then multiply to form newly detected tumors that are increasingly resistant to treatment. The growing popularity of “cocktails” of chemotherapy drugs has given rise to multidrug resistant tumor cells that are even more difficult to destroy.
Drug sensitive tumor cells, under the selective pressure of treatment with drugs, develop into drug resistant versions of the same tumor cell type. It is the drug resistant cells that take over, and with each round of chemotherapy the proportion of drug resistant cells to drug sensitive cells increases, to the point where recovery becomes more and more difficult. Eventually the cancer becomes untreatable.
“Drug resistance, either acquired or inherent, is the leading cause of death in cancer, a disease that kills at least 6.2 million people worldwide annually,” said Viral Genetics CEO
Viral Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The company recently entered into an Exclusive License Agreement with the
This news release contains forward-looking statements that involve risks and uncertainties associated with financial projections, budgets, milestone timelines, clinical development, regulatory approvals, and other risks described by Viral Genetics, Inc. from time to time in its periodic reports filed with the SEC and after
Contact: Viral Genetics Haig Keledjian, 626-334-5310
SOURCE Viral Genetics, Inc.