Coronary Artery Dilation Among Patients Presenting With Systemic- Onset Juvenile Idiopathic Arthritis
Posted on: Sunday, 10 July 2005, 03:01 CDT
e89 ABSTRACT. Coronary Artery Dilation Among Patients Presenting With Systemic-Onset Juvenile Idiopathic Arthritis. Bryce A. Binstadt, MD, PhD; Jami C. Levine, MD; Peter A. Nigrovic, MD; Kimberlee Gauvreau, DSci; Fatma Dedeoglu, MD; Robert C. Fuhlbrigge, MD, PhD; Steven N. Weindling, MD; Jane W. Newburger, MD, MPH; and Robert P. Sundel, MD. Objective. To evaluate coronary artery diameters among patients presenting with systemic-onset juvenile idiopathic arthritis (SoJIA).
Methods. Fifty cases of SoJIA were reviewed. At the time of initial presentation with fever, 12 patients had echocardiograms that included a complete evaluation of the coronary arteries. A single reviewer measured the diameters of the left main, proximal left anterior descending, and proximal right coronary arteries. Body surface area-adjusted z scores were calculated with respect to a normative population.
Results. Coronary artery dilation (z score: >2) was observed for 5 of the 12 patients with SoJIA who had echocardiograms performed at the time of presentation with fever. No patient developed a coronary artery aneurysm, and all of the coronary artery z scores normalized within 4 months. Only 2 of the 5 patients with coronary artery z scores of >2 fulfilled the clinical criteria for Kawasaki disease, the most commonly recognized cause of coronary artery dilation among children.
Conclusions. Children presenting with SoJIA may have coronary artery dilation similar to that observed for children with Kawasaki disease. These data suggest that the presence of coronary artery dilation on initial echocardiograms for patients with fever does not exclude the diagnosis of SoJIA. Pediatrics 2005;116:e89-e93. URL: www.pediatrics.org/cgi/doi/10.1542/peds.2004-2190; juvenile rheumatoid arthritis, Still's disease, Kawasaki disease, fever.
Copyright American Academy of Pediatrics Jul 2005
Source: Pediatrics
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