New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance
Faster reporting aids physicians in identifying HIV mutations that can inhibit effectiveness of newest class of antiretroviral therapy
“Diagnostic testing is at the center of personalized medicine, providing genetic insights necessary to understand which medicines are most likely to produce a favorable health outcome for the individual patient,” said
HIV coreceptor tropism refers to the preference of strains of HIV to bind to, activate and infect cells, promoting disease progression, based on the type of coreceptor on the cell’s surface. The newest class of antiretroviral drugs, called entry inhibitors, targets the tropism process involving one or both coreceptors, CCR5 or CXCR4, of CD4 cells, which help the immune system fight infection. HIV-1 viral particles that use the CCR5 coreceptor to infect the cell are called R5-tropic, those using CXCR4 are called X4-tropic, and those using both are called dual-tropic. X4- and dual-tropic viruses typically emerge after years of infection and are found in up to half of patients with a history of drug resistance or those with advanced disease. Guidelines from the U.S. Department of Health and Human Services recommend tropism testing prior to the start of a CCR5 inhibitor, such as maraviroc (Selzentry TM). Three out of four people taking HIV drugs experience treatment failure linked to drug resistance.
“CCR5 antagonist entry inhibitors have given physicians new options for treating thousands of patients with HIV who have shown resistance to earlier HIV therapies. Yet, they are only suitable for about half of these patients due to different ways the virus tries to infect cells,” said
At the XVIII International HIV Drug Resistance Workshop in Fort Meyers,
Quest Diagnostics had offered a prior version of the SensiTrop test through a license with Pathway Diagnostics before acquiring the company during the fourth quarter 2008. The company’s new HIV-1 Coreceptor test employs a novel molecular-based technology developed by Quest Diagnostics scientists.
The Quest Diagnostics HIV laboratory testing services menu is the most comprehensive in the diagnostic industry. In addition to HIV tropism testing, the company’s test services range from HIV diagnostic testing to monitoring HIV viral load, determining a viral genotype, and testing for the HLA-B*5701 genetic marker as an aid in predicting a hypersensitivity reaction to abacavir (Ziagen(R)), an antiretroviral therapy.
About HIV and AIDS
HIV, or the human immunodeficiency virus, is a retrovirus that infects cells of the human immune system, destroying or impairing their function. The two major viruses that cause AIDS are HIV-1 and HIV-2. The most common, HIV-1, is found worldwide, while HIV-2 is primarily confined to
About Quest Diagnostics
Quest Diagnostics is the world’s leading provider of diagnostic testing, information and services that patients and doctors need to make better healthcare decisions. The company offers the broadest access to diagnostic testing services through its network of laboratories and patient service centers, and provides interpretive consultation through its extensive medical and scientific staff. Quest Diagnostics is a pioneer in developing innovative diagnostic tests and advanced healthcare information technology solutions that help improve patient care. Additional company information is available at www.QuestDiagnostics.com.
The statements in this press release which are not historical facts may be forward-looking statements. Readers are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date that they are made and which reflect management’s current estimates, projections, expectations or beliefs and which involve risks and uncertainties that could cause actual results and outcomes to be materially different. Risks and uncertainties that may affect the future results of the company include, but are not limited to, adverse results from pending or future government investigations, lawsuits or private actions, the competitive environment, changes in government regulations, changing relationships with customers, payers, suppliers and strategic partners and other factors discussed in “Business” in Part I, Item 1, “Risk Factors” and “Cautionary Factors that May Affect Future Results” in Part I, Item 1A, “Legal Proceedings” in Part I, Item 3, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Part II, Item 7 and “Quantitative and Qualitative Disclosures About Market Risk” in Part II, Item 7A in the company’s 2008 Annual Report on Form 10-K and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and “Quantitative and Qualitative Disclosures About Market Risk” in the company’s 2009 Quarterly Report on Form 10-Q and other items throughout the Form 10-K and the company’s 2009 Quarterly Reports on Form 10-Q and Current Reports on Form 8-K.
Trofile is a trademark of Monogram Biosciences, Inc.
Selzentry is a trademark of Pfizer Inc.
ZIAGEN(R) is a registered trademark, used under license by GlaxoSmithKline Inc.
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Quest Diagnostics Contacts: Laure Park (Investors): 973-520-2900 Wendy Bost (Media): 973-520-2800
SOURCE Quest Diagnostics Incorporated