Abbott and Oasmia Pharmaceutical Announce Exclusive Distribution Agreement for Paccal(R) Vet, a New Chemotherapeutic Agent for Dogs
ABBOTT PARK, Ill. and UPPSALA,
Under the terms of the agreement, Abbott will obtain exclusive rights to distribute Paccal Vet for veterinary use in
Paccal Vet is a new formulation of the active ingredient paclitaxel. Paclitaxel has been used in treating cancer in humans since 1993. Traditional formulations of paclitaxel were insoluble in water, thus requiring the medication to be dissolved in solvents, which led to low tolerability and severe adverse effects in dogs. Paccal Vet uses a novel, non-toxic nanoparticle formulation that overcomes those challenges and provides a high level of water solubility. If approved, Paccal Vet would be one of the first cancer treatments specifically designed for veterinary use.
The move into veterinary oncology adds a new focus area to Abbott’s existing Animal Health research and product lines, which include diabetes, anesthesia, wound care, pain management and fluid therapy.
“There are significant unmet needs in this market, which is why Abbott is entering the veterinary oncology arena,” said
“Oasmia is pleased to announce this agreement with Abbott for the largest market within veterinary medicine,” said
About Paccal(R) Vet
With the retinoid based unique platform XR-17, Oasmia developed a water soluble formulation of paclitaxel (Paccal(R) Vet), that does not require premedication and abolishes Cremophor(R) EL related side effects. Two clinical trials have been performed in client owned dogs with tumors refractory to standard treatment. The results are very promising, both regarding tolerability and tumor response. In one clinical study of dogs with Grade II/III mast cell tumors, the overall response rate (either complete disappearance of all signs of cancer or the tumor shrinks or stops growing completely) was 69.5 percent.(1) The studies also show that the pharmacokinetic and side-effect profiles in dogs are supported by parallel trials in humans.
Oasmia Pharmaceutical AB develops second and third generation cancer drugs based on nanotechnology for human and veterinary use. The broad portfolio is focused on oncology and contains several promising products in the clinical and pre-clinical phase. Oasmia cooperates with leading universities and other biotech companies to discover and optimize substances with a favorable safety profile and better efficacy. The company name was registered in 1999 and is based in Uppsala,
Oasmia’s news releases and other information are available on the company’s website www.oasmia.com.
About Abbott Animal Health
Abbott Animal Health is dedicated to providing a better future for animals, owners and veterinary professionals. Abbott’s continuing education programs, comprehensive training tools, on-call expertise and technical service set the standard in the industry. Abbott products are trusted at thousands of veterinary hospitals and clinics every day.
Abbott is global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals and medical products, including nutritionals, devices and diagnostics. The company employs more than 72,000 people and markets its products in more than 130 countries.
Abbott’s news releases and other information are available on the company’s Web site at www.abbott.com.
(1) von Euler H, Akerlund-Denneberg N, Rivera P, Bergvall K, Kessler M, Rowe A, Willmann M, Persson G, Kastengren Froberg G, Westberg S and Kristianson K. Efficacy and safety in an open label single arm multi center phase III trial of a new formulation of paclitaxel (Paccal(R) Vet) in dogs with mast cell tumours grade II and III. ESVONC Annual Congress