July 13, 2009

Common Infant Tumor Has A Nox(4)ious Requirement

Hemangiomas are the most common tumor of infancy. They are benign tumors derived from cells that line blood vessels (endothelial cells) and spontaneously regress as a child gets older. Jack Arbiser and colleagues, at Emory University School of Medicine, Atlanta, have now provided new insight into the molecules that control hemangioma growth and found that inhibiting a key molecule substantially inhibits hemangioma growth in a mouse model. Specifically, the protein Nox4 was found to be crucial for hemangioma growth in a mouse model and the drug fulvene 5 was found to be a potent in vitro inhibitor of Nox4 and to substantially inhibit in vivo hemangioma growth. The authors therefore suggest that targeting Nox4, potentially using fulvene derivatives, might provide a way to attenuate hemangioma growth.


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Journal of Clinical Investigation