July 31, 2009
Scientist: Red wine secret uncorked
Scientists in Scotland and Singapore say they have unraveled how red wine's resveratrol controls inflammation.
Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment, Alirio Melendez of Glasgow Biomedical Research Centre in Scotland says in a statement.
Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs.
The researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol experienced a strong inflammatory response, simulating disease in humans while the group pretreated with resveratrol was protected from the inflammation.
The study, published in The Federation of American Societies for Experimental Biology Journal, found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation -- sphingosine kinase and phospholipase D.