Predictors Show A Disease Behavior Change In Crohn’s Disease
Posted on: Monday, 10 August 2009, 11:00 CDT
Using the Vienna classification system, it has been shown in clinic-based cohorts that there can be a significant change in disease behavior over time, whereas disease location remains relatively stable. Clinical and environmental factors as well as medical therapy might be relevant in predicting disease behavior change in patients with CD. In previous studies, early age at diagnosis, disease location, perianal disease and, in some studies, smoking were associated with the presence of complicated disease and surgery.The combined effect of markers of disease phenotype (e.g., age, gender, location, perianal diesease) and medical therapy (steroid use, early immunosupression) on the probability of disease behavior change were, however, not studied thus far in the published literature.
A research article to be published on July 28, 2009 in the World Journal of Gastroenterology addresses this question . Members of the Hungarian IBD Study Group led by Dr Peter Laszlo Lakatos from the Semmelweis University investigated 340 well-characterized, unrelated, consecutive CD patients (M/F: 155/185, duration: 9.4 ± 7.5 years) with a complete clinical follow-up. Medical records including disease phenotype according to the Montreal classification, extraintestinal manifestations, use of medications and surgical events were analyzed retrospectively. Patients were interviewed on their smoking habits at the time of diagnosis and during the regular follow-up visits.
They found that perianal disease, current smoking, prior steroid use, early azathioprine or azathioprine/biological therapy are predictors of disease behavior change in CD patients.
The new data with easily applicable clinical information as presented in the article may assist clinicians in practical decision-making or in choosing the treatment strategy for their CD patients.
--------------
On The Net:
World Journal of Gastroenterology
Related Articles
- The Lancet Neurology Publishes Clinical Results of PBT2 in Alzheimer's Disease Patients
- Handbook of Tuberculosis Clinics Diagnostics Therapy and Epidemiology is the Third Volume in This Comprehensive Series on This Deadly Airborne Disease
- Study Validates Medication Therapy Management Principles
- Focus On the Current Art and Science of Clinically Available Drugs for the Medical Therapy of Glaucoma With This Recent Book
- HealthMedia Creates 'Blue Ocean' for Disease Management and Behavioral Health Space
- Humana Launches Medication Therapy Management Program to Provide Clinical and Economic Guidance to Medicare Members; Program Will Assist Beneficiaries in Optimizing Therapeutic Outcomes, Reducing the Risk of Adverse Drug Events
- Pervasis Therapeutics Expands Team to Bring to Market Medical Therapies for Treating Cardiovascular Diseases
- New Study Data in December 9th New England Journal of Medicine Shows Medication May Help Parkinson's Disease Patients With Dementia
- Pretransplant Psychiatric and Medical Comorbidity of Alcoholic Liver Disease Patients Who Received Liver Transplant
- Lowering BP With Medication Provides Unexpected Benefits for Heart Disease Patients With 'Normal' Blood Pressure
Rating: 3.7 / 5 (3 votes)
 |
 |
Rate this article:
User Comments (0)
RSS Feeds