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New Drug-Resistant TB Strains Could Become Widespread

August 13, 2009

New forms of tuberculosis could swell the proportion of drug-resistant cases globally, a new study has found. Although TB incidence is falling in many regions, the emergence of antibiotic resistance could see virtually untreatable strains of the disease become widespread.

Laboratory-based studies conducted by Australian researchers from the University of New South Wales and the University of Western Sydney have suggested that antibiotic-resistant TB strains cause longer-lasting infections but with a lower transmission rate. Therefore, scientists have questioned whether drug-resistant TB strains are more likely than drug-sensitive strains to persist and spread ““ an important question for predicting the future impact of the disease.

One in three humans already carries the TB bacterium. Although it remains latent in most cases, the World Health Organization (WHO) has estimated there were 9.27 million new cases of TB in 2007. There were 1.6 million TB-related deaths in 2005.

Drug-resistant TB is caused by inconsistent or partial treatment, when patients do not take all their medicines regularly for the required period or because the drug supply is unreliable.

A research team led by UNSW’s Dr. Mark Tanaka used epidemiological and molecular data from Mycobacterium tuberculosis strains isolated from Cuba, Estonia and Venezuela to estimate the rate of evolution of drug resistance and to compare the relative “reproductive fitness” of resistant and drug-sensitive strains. “We found that the overall fitness of drug-resistant strains is comparable to drug-sensitive strains,” Dr. Tanaka of the Evolution and Ecology Research Centre was quoted as saying. “This was especially so in Cuba and Estonia, where the there is a high prevalence of drug-resistant cases.”

The finding may reflect an inconsistency in drug treatment programs in these countries. Indeed, Estonia now has one of the highest rates of multi-drug resistance in the world. The intermittent presence of drugs and the resulting transmission of resistant strains would have let drug-resistant strains spend more time within untreated hosts, allowing them to evolve ways to become more infectious and to out-compete the drug-sensitive strains.

The study also reveals that transmission of drug resistant strains is very high ““ up to 99 per cent ““ compared with acquired resistance due to treatment failure. “Our results imply that drug resistant strains of TB are likely to become highly prevalent in the next few decades,” UNSW’s Dr Fabio Luciani, the study’s lead author was quoted as saying. “They also suggest that limiting further transmission of TB might be an effective approach to reducing the impact of drug resistance.”

“Mathematical and statistical methods can add a lot of value to empirical data by allowing us to account for the processes behind them,” research co-author, Dr. Andrew Francis from the University of Western Sydney is quoted as saying. “In this case, we use samples of TB genotypes, together with information about drug resistance, to make inferences and predictions that wouldn’t have been possible just a few years ago.”

SOURCE:  Proceedings of the National Academy of Sciences, August 10, 2009




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