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Treatment For Dementia Associated With Risk Of Hospitalization

Posted on: Tuesday, 29 September 2009, 09:57 CDT

Laura Park-Wyllie and colleagues, from St Michael's Hospital, Toronto, examined the health records of more than 1.4 million older adults in Ontario and showed that initiation of cholinesterase inhibitor therapy – a common treatment for dementia –is associated with a more than doubling of the risk of hospitalization for bradycardia.

Funding: LYPW was supported by a fellowship from the Canadian Institutes for Health Research. SSG was supported by a Career Scientist Award from the Ontario Ministry of Health and Long-Term Care. DNJ was supported by a New Investigator Award from the Canadian Institutes for Health Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: MMM was employed at Pfizer Global Pharmaceuticals from January 2006 to April 2007.

Citation: Park-Wyllie LY, Mamdani MM, Li P, Gill SS, Laupacis A, et al. (2009) Cholinesterase Inhibitors and Hospitalization for Bradycardia: A Population-Based Study. PLoS Med 6(9): e1000157. doi:10.1371/journal.pmed.1000157

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